Search Results - "translational science"

Totality of evidence of the effectiveness of repurposed therapies for COVID‐19: Can we use real‐world studies alongside randomized controlled trials? by Jaap Mandema, Hugh Montgomery, Louis Dron, Shuai Fu, Estelle Russek‐Cohen, Christina Bromley, Samer Mouksassi, Amy Lalonde, Aaron Springford, Larry Tsai, Phil Ambery, Doug McNair, Nawab Qizilbash, Stuart Pocock, Névine Zariffa

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A phase I randomized study to evaluate safety, pharmacokinetics, and pharmacodynamics of SIR2446M, a selective RIPK1 inhibitor, in healthy participants by Ana Liza Andresan Sun, John David Gillies, Yang Shen, Huajun Deng, Fenchao Xue, Yongfen Ma, Linan Song

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Influence of 4‐week or 12‐week glucocorticoid treatment on metabolic changes in patients with active moderate‐to‐severe thyroid‐associated ophthalmopathy by Xiaoman Chen, Buatikamu Abudukerimu, Qin Li, Qing Li, Jie Qiao, Dongping Lin, Chunhua Sui, Lin Ye, Hualing Zhai, Boren Jiang, Ningjian Wang, Mengda Jiang, Xiaofeng Tao, Ziyang Shao, Chenfang Zhu, Yubo Ma, Ping Xiong, Jing Sun, Huifang Zhou, Bing Han, Yingli Lu

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Clinical Pharmacokinetics and Pharmacodynamics of Cerliponase Alfa, Enzyme Replacement Therapy for CLN2 Disease by Intracerebroventricular Administration by Aryun Kim, Anita Grover, Kevin Hammon, Greg deHart, Peter Slasor, Anu Cherukuri, Temitayo Ajayi, David Jacoby, Angela Schulz, Nicola Specchio, Emily deLos Reyes, Paul Gissen, Joshua W. Henshaw

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A phase I, open‐label, single‐dose study to evaluate the effect of hepatic impairment on the pharmacokinetics and safety of futibatinib by Ling Gao, Ikuo Yamamiya, Mark Pinti, Juan Carlos Rondon, Thomas Marbury, Gareth Tomlinson, Lukas Makris, Nanae Hangai, Volker Wacheck

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Facilitators and barriers to pediatric clinical trial recruitment and retention in rural and community settings: A scoping review of the literature by Sara E. Watson, Paul Smith, Jessica Snowden, Vida Vaughn, Lesley Cottrell, Christi A. Madden, Alberta S. Kong, Russell McCulloh, Crystal Stack Lim, Megan Bledsoe, Karen Kowal, Mary McNally, Lisa Knight, Kelly Cowan, Elizabeth Yakes Jimenez

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Pairwise comparison of hydrochlorothiazide and chlorthalidone responses among hypertensive patients by Lakshmi Manasa S. Chekka, Rhonda M. Cooper‐DeHoff, John G. Gums, Arlene B. Chapman, Julie A. Johnson

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PBPK‐led assessment of antimalarial drugs as candidates for Covid‐19: Simulating concentrations at the site of action to inform repurposing strategies by Nada Abla, Lisa M. Almond, Jennifer J. Bonner, Naomi Richardson, Timothy N. C. Wells, Jörg J. Möhrle

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Safety and Pharmacokinetics of the Oral TYK2 Inhibitor PF‐06826647: A Phase I, Randomized, Double‐Blind, Placebo‐Controlled, Dose‐Escalation Study by Ravi Shankar P. Singh, Vivek Pradhan, Erika S. Roberts, Matthew Scaramozza, Elizabeth Kieras, Jeremy D. Gale, Elena Peeva, Michael S. Vincent, Anindita Banerjee, Andrew Fensome, Martin E. Dowty, Peter Winkle, Christopher Tehlirian

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A Double‐Blind, Phase I, Single Ascending Dose Study to Assess the Safety, Pharmacokinetics, and Pharmacodynamics of BOS161721 in Healthy Subjects by Azra Hussaini, Rajat Mukherjee, Dina M. Berdieva, Christen Glogowski, Richard Mountfield, Peter T.C. Ho

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Early changes in soluble intracellular adhesion molecule‐1 as prognostic biomarkers to immune checkpoint inhibitor by Dongmei Ji, Shiyu Jiang, Qunling Zhang, Y. Ken Wang, Jian Zhang, Weina Shen, Wenhua Li, Rujiao Liu, Jessica Wang, Cory Mavis, Juan J. Gu, Xichun Hu

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Impact of NFIB and CYP1A variants on clozapine serum concentration-A retrospective naturalistic cohort study on 526 patients with known smoking habits by Hasan Çağın Lenk, Robert Løvsletten Smith, Kevin S. O'Connell, Marin M. Jukić, Marianne Kristiansen Kringen, Ole A. Andreassen, Magnus Ingelman‐Sundberg, Espen Molden

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Oral and intravenous pharmacokinetics of metformin with and without oral codeine intake in healthy subjects: A cross‐over study by Ida Kuhlmann, Amanda Nøddebo Nyrup, Tore Bjerregaard Stage, Mette Marie Hougaard Christensen, Troels Korshøj Bergmann, Per Damkier, Flemming Nielsen, Kurt Højlund, Kim Brøsen

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Functional differences in the mu opioid receptor SNP 118A>G are dependent on receptor splice‐variant and agonist‐specific recruitment of β‐arrestin by Casey Patrick, Utibeabasi Ettah, Vu Nguyen, Caitlin Hart, Evan Atchley, Krishna Mallela, Robert I. Scheinman, Andrew A. Monte

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Mortality factors and antibiotic options in carbapenem‐resistant Enterobacterales bloodstream infections: Insights from a high‐prevalence setting with co‐occurring NDM‐1 and OXA‐48... by Palat Karnmueng, Preecha Montakantikul, Taniya Paiboonvong, Rongpong Plongla, Tanittha Chatsuwan, Supatat Chumnumwat

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Reduced tear thrombospondin‐1/matrix metalloproteinase‐9 ratio can aid in detecting Sjögren's syndrome etiology in patients with dry eye by Sharmila Masli, Esen K. Akpek

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Uncovering the Genomic Landscape in Newly Diagnosed and Relapsed Pediatric Cytogenetically Normal FLT3‐ITD AML by Daelynn R. Buelow, Stanley B. Pounds, Yong‐Dong Wang, Lei Shi, Yongjin Li, David Finkelstein, Sheila Shurtleff, Geoffrey Neale, Hiroto Inaba, Raul C. Ribeiro, Reid Palumbo, Dominique Garrison, Shelley J. Orwick, James S. Blachly, Karl Kroll, John C. Byrd, Tanja A. Gruber, Jeffrey E. Rubnitz, Sharyn D. Baker

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Social network analysis of the CaRE2 health equity center: Team science in full display by Miriam O. Ezenwa, Thomas Bryan Smith, Joyce Richey, Ukamaka D. Smith, Mariana C. Stern, Renee Reams, Diana J. Wilkie

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Remibrutinib (LOU064): A selective potent oral BTK inhibitor with promising clinical safety and pharmacodynamics in a randomized phase I trial by Martin Kaul, Peter End, Maciej Cabanski, Carole Schuhler, Annamaria Jakab, Magdalena Kistowska, Arvind Kinhikar, Alessio Maiolica, Angela Sinn, Rainard Fuhr, Bruno Cenni

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Cambio climático y enfermedades transmitidas por vectores. Convertir el conocimiento en acción by Clara Bermúdez-Tamayo, Leticia García Mochón, Ainhoa Ruiz Azarola, Marina Lacasaña

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