Search Results - "translational science"

Pharmacokinetics, pharmacodynamics, and exposure-efficacy of dupilumab in adults with atopic dermatitis by Mohamed A. Kamal, John D. Davis, Pavel Kovalenko, Kamal Srinivasan, Eric L. Simpson, Takeshi Nakahara, Makoto Sugaya, Atsuyuki Igarashi, Marius Ardeleanu, Christine Xu, Kazuhiko Arima

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A randomized, placebo‐controlled first‐in‐human study of oral TQS‐168 in healthy volunteers: Assessment of safety, tolerability, pharmacokinetics, pharmacodynamics, and food effect... by Jonas Hannestad, Steven Smith, Andrew Lam, Janet Hurt, Nicole Harada, Richard Kim, Abhirup Das, Juliana Brunello, Gareth Whitaker, David Chalmers, Faria Senjoti, Wu Lin, James Coghill, Yogesh Bansal, Sharan Sidhu, Vanessa Zann, Enchi Liu

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St. John's wort extract with a high hyperforin content does not induce P‐glycoprotein activity at the human blood-brain barrier by Myriam El Biali, Michael Wölfl‐Duchek, Matthias Jackwerth, Severin Mairinger, Maria Weber, Karsten Bamminger, Stefan Poschner, Ivo Rausch, Natalie Schindler, Irene Hernández Lozano, Walter Jäger, Lukas Nics, Nicolas Tournier, Marcus Hacker, Markus Zeitlinger, Martin Bauer, Oliver Langer

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The adiponectin‐derived peptide ALY688 protects against the development of metabolic dysfunction‐associated steatohepatitis by Zhe Huang, Hye Kyoung Sung, Xingqun Yan, Shiyu He, Leigang Jin, Qin Wang, Xuerui Wu, Henry H. Hsu, Angelica Pignalosa, Kathryn Crawford, Gary Sweeney, Aimin Xu

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Safety, pharmacokinetics, and target engagement of a brain penetrant RIPK1 inhibitor, SAR443820 (DNL788), in healthy adult participants by Agnes Hincelin‐Mery, Xavier Nicolas, Cathy Cantalloube, Robert Pomponio, Pascale Lewanczyk, Myriam Benamor, Dimitry Ofengeim, Emmanuel Krupka, Jennifer Hsiao‐Nakamoto, Amy Eastenson, Nazem Atassi

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Clinical, methodology, and patient/carer expert advice in pediatric drug development by conect4children by Katharine Cheng, Fenna Mahler, Irja Lutsar, Begonya Nafria Escalera, Stefanie Breitenstein, Gilles Vassal, Joana Claverol, Nuria Noel Palacio, Ron Portman, Gavin Pope, Martijn Bakker, Tessa van derGeest, Mark A. Turner, Saskia N. deWildt, c4c Expert Group Leads

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Pharmacogenetic testing among patients with depression in a US managed care population by Heather D. Anderson, Thida M. Thant, David P. Kao, Kristy R. Crooks, Nicholas D. Mendola, Christina L. Aquilante

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Rituximab exposure‐response in triweekly R‐CHOP treatment in DLBCL: A loading dose is recommended to improve clinical outcomes by Shu Liu, Zhao Wang, Rongxin Chen, He Huang, Xueding Wang, Chen Peng, Yanping Guan, Xiaojie Fang, Shaoxing Guan, Hongbing Huang, Tao Liu, Tongyu Lin, Min Huang

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A linked physiologically based pharmacokinetic model for hydroxychloroquine and metabolite desethylhydroxychloroquine in SARS‐CoV‐2(−)/(+) populations by Claire Steinbronn, Yashpal S. Chhonker, Jenell Stewart, Hannah Leingang, Kate B. Heller, Meighan L. Krows, Michael Paasche‐Orlow, Anna Bershteyn, Helen C. Stankiewicz Karita, Vaidehi Agrawal, Miriam Laufer, Raphael Landovitz, Mark Wener, Daryl J. Murry, Christine Johnston, Ruanne V. Barnabas, Samuel L. M. Arnold

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Real‐world implementation of DPYD and UGT1A1 pharmacogenetic testing in a community‐based cancer center by Megan Muldoon, Mollie Beck, Nichlas Sebree, Robin Yoder, Stacey Ritter, Josiah D. Allen, Zuhair Alqahtani, Jaime Grund, Brooke Philips, Kristina Hesse, Nihal El Rouby

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Pharmacoenhancement of Low Crizotinib Plasma Concentrations in Patients with Anaplastic Lymphoma Kinase‐Positive Non‐Small Cell Lung Cancer using the CYP3A Inhibitor Cobicistat by Nicolas Hohmann, Farastuk Bozorgmehr, Petros Christopoulos, Gerd Mikus, Antje Blank, Jürgen Burhenne, Michael Thomas, Walter E. Haefeli

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Immunogenicity of avelumab in patients with metastatic Merkel cell carcinoma or advanced urothelial carcinoma by Ping Hu, Haiqing Isaac Dai, James Bourdage, Dongli Zhou, Ky Trang, Karey Kowalski, Carlo Bello, Jennifer Hibma, Akash Khandelwal, Kyra Cowan, Jennifer Dong, Karthik Venkatakrishnan, Wei Gao

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A long‐acting GDF15 analog causes robust, sustained weight loss and reduction of food intake in an obese nonhuman primate model by Songmao Zheng, David Polidori, Yuanping Wang, Brian Geist, Xiefan Lin‐Schmidt, Jennifer L. Furman, Serena Nelson, Andrea R. Nawrocki, Simon A. Hinke

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Protocol of the IntenSify‐Trial: An open‐label phase I trial of the CYP3A inhibitor cobicistat and the cytostatics gemcitabine and nab‐paclitaxel in patients with advanced stage or... by Nicolas Hohmann, Martin Ronald Sprick, Moritz Pohl, Azaz Ahmed, Jürgen Burhenne, Marietta Kirchner, Lucian Le Cornet, Markus Kratzmann, Jacek Hajda, Albrecht Stenzinger, Karen Steindorf, Stefan Delorme, Heinz‐Peter Schlemmer, Sabine Riethdorf, Ron vanSchaik, Klaus Pantel, Jens Siveke, Thomas Seufferlein, Dirk Jäger, Walter E. Haefeli, Andreas Trumpp, Christoph Springfeld

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Clinical dose rationale of tislelizumab in patients with solid or hematological advanced tumors by Tian Yu, Xiangyu Liu, Chi‐Yuan Wu, Zhiyu Tang, Hongwei Wang, Patrick Schnell, Ya Wan, Kun Wang, Lucy Liu, Yuying Gao, Srikumar Sahasranaman, Nageshwar Budha

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Population pharmacokinetic and exposure‐response analyses from ALTA‐1L: Model‐based analyses supporting the brigatinib dose in ALK‐positive NSCLC by Neeraj Gupta, Karen L. Reckamp, David R. Camidge, Huub J. Kleijn, Aziz Ouerdani, Francesco Bellanti, John Maringwa, Michael J. Hanley, Shining Wang, Pingkuan Zhang, Karthik Venkatakrishnan

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Clinical assessment of momelotinib drug-drug interactions via CYP3A metabolism and transporters by Yu Liu Ho, Pete Gorycki, Geraldine Ferron‐Brady, Paul Martin, Georgios Vlasakakis

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Feasibility and accuracy of mobile QT interval monitoring strategies in bedaquiline‐enhanced prophylactic leprosy treatment by Auke T. Bergeman, Said Nourdine, Alberto Piubello, Zahara Salim, Sofie M. Braet, Abdallah Baco, Silahi H. Grillone, Rian Snijders, Carolien Hoof, Achilleas Tsoumanis, Harry vanLoen, Younoussa Assoumani, Aboubacar Mzembaba, Nimer Ortuño‐Gutiérrez, Epco Hasker, Christian van derWerf, Bouke C. deJong

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Clinical pharmacokinetics and pharmacodynamics of ongericimab: A potential long‐acting PCSK9 monoclonal antibody in healthy subjects and patients with hypercholesterolemia: Randomi... by Juanjuan Jiang, Li Xu, Lin Chai, Xiaoyuan Guan, Li Zhang, Hong Liu, Yan Yan, Lili Li, Yi Zhao, Xuelian Bai, Lei Tian, Youhong Jia

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Impact of pretreatment dihydropyrimidine dehydrogenase genotype‐guided fluoropyrimidine dosing on chemotherapy associated adverse events by Theodore J. Wigle, Brandi L. Povitz, Samantha Medwid, Wendy A. Teft, Robin M. Legan, John Lenehan, Stephanie Nevison, Veera Panuganty, Denise Keller, Jaymie Mailloux, Victoria Siebring, Sisira Sarma, Yun‐hee Choi, Stephen Welch, Eric Winquist, Ute I. Schwarz, Richard B. Kim

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