Search Results - "translational science"

Effect of enzalutamide on PK of P‐gp and BCRP substrates in cancer patients: CYP450 induction may not always predict overall effect on transporters by Srinivasu Poondru, Vitalii Ghicavii, Reza Khosravan, Pooja Manchandani, Nakyo Heo, Selina Moy, Tomasz Wojtkowski, Melanie Patton, Gabriel P. Haas

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Edoxaban for the Long‐Term Therapy of Venous Thromboembolism: Should the Criteria for Dose Reduction be Revised? by Giuseppe Camporese, Paolo Simioni, Pierpaolo Di Micco, Carmen Fernández‐Capitán, Agustina Rivas, Carme Font, Joan Carles Sahuquillo, Paula Villares, Paolo Prandoni, Manuel Monreal, and the RIETE Investigators

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A Randomized Phase I Study to Evaluate the Safety, Tolerability, and Pharmacokinetics of Recombinant Erwinia Asparaginase (JZP‐458) in Healthy Adult Volunteers by Tong Lin, Martha Hernandez‐Illas, Andres Rey, Jack Jenkins, Reddy Chandula, Jeffrey A. Silverman, Mi Rim Choi

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Randomized, double‐blind, phase 1a single‐ascending dose and food effect studies assessing safety and pharmacokinetics of EC5026 in healthy volunteers by William K. Schmidt, Irene Cortés‐Puch, Cindy B. McReynolds, Glenn E. Croston, Sung Hee Hwang, Jun Yang, Theresa L. Pedersen, Karen M. Wagner, Theresa T. Pham, Thomas Hunt, Bruce D. Hammock

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An evaluation on the association of vancomycin trough concentration with mortality in critically ill patients: A multicenter retrospective study by Jiajia Ren, Yanli Hou, Jiamei Li, Ya Gao, Ruohan Li, Xuting Jin, Jingjing Zhang, Xiaochuang Wang, Gang Wang

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Regulatory guidelines do not accurately predict tolvaptan and metabolite interactions at BCRP, OATP1B1, and OAT3 transporters by Susan E. Shoaf, Patricia Bricmont, Jennifer Repella Gordon

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Using Innovation-Corps (I-Corps™) Methods to Adapt a Mobile Health (mHealth) Obesity Treatment for Community Mental Health Settings by Rita Haddad, Carolina Badke D'Andrea, Amanda Ricchio, Bradley Evanoff, Elaine H. Morrato, Elaine H. Morrato, Joseph Parks, John W. Newcomer, John W. Newcomer, Ginger E. Nicol

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Randomized, placebo‐controlled, double‐blind phase I trial of co‐administered pyronaridine and piperaquine in healthy adults of sub‐Saharan origin by Andrea Kuemmerle, Denis Gossen, Annick Janin, Andrew Stokes, Nada Abla, Maja Szramowska, Ulrike Lorch, Myriam El Gaaloul, Isabelle Borghini‐Fuhrer, Stephan Chalon

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Incidence of complications from indwelling pleural catheter for pleural effusion: A meta‐analysis by Shuyan Wang, Rui Zhang, Chun Wan, Jiangyue Qin, Xueru Hu, Yongchun Shen, Lei Chen, Fuqiang Wen

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Mitochondrial function, grip strength, and activity are related to recovery of mobility after a total knee arthroplasty by Marcus P. J. vanDiemen, Dimitrios Ziagkos, Matthijs D. Kruizinga, Menno R. Bénard, Philip Lambrechtse, Joris A. J. Jansen, Barbara A. M. Snoeker, Maaike G. J. Gademan, Adam F. Cohen, Rob G. H. H. Nelissen, Geert Jan Groeneveld

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Effects of the selective AMPA modulator NBI‐1065845 on the pharmacokinetics of midazolam or ethinyl estradiol-levonorgestrel in healthy adults by Swan Lin, Adrian Ionescu, Jessica Maynard‐Scott, Mike Kennedy, David P. Walling, Maura Furey, Jaskaran B. Singh

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G970R‐CFTR Mutation (c.2908G>C) Results Predominantly in a Splicing Defect by Meredith C. Fidler, Alexandra Buckley, James C. Sullivan, Marvin Statia, Sylvia F. Boj, Robert G. J. Vries, Anne Munck, Mark Higgins, Matteo Moretto Zita, Paul Negulescu, Fredrick vanGoor, Kris De Boeck

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A longitudinal study of cytochrome P450 2D6 (CYP2D6) activity during adolescence by J. Steven Leeder, Andrea Gaedigk, Krista J. Wright, Vincent S. Staggs, Sarah E. Soden, Yvonne S. Lin, Robin E. Pearce

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A systematic review and meta‐analysis of the impacts of germline pharmacogenomics on severe toxicity and symptom burden in adult patients with cancer by Senthil Lingaratnam, Mahek Shah, Joseph Nicolazzo, Michael Michael, John F. Seymour, Paul James, Smaro Lazarakis, Sherene Loi, Carl M. J. Kirkpatrick

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In vivo tissue pharmacokinetics of ERBB2‐specific binding oligonucleotide‐based drugs by PET imaging by Sun Mi Park, Suji Baek, Jung Hwan Lee, Sang‐Keun Woo, Tae Sup Lee, Hyun Soo Park, Jongook Lee, Yeon‐Koo Kang, Seo Young Kang, Min Young Yoo, Hai‐Jeon Yoon, Bom Sahn Kim, Kang Pa Lee, Byung Seok Moon

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Plerixafor for pathogen‐agnostic treatment in murine thigh infection and zebrafish sepsis by Martin O. Evans, Darren M. Smith, Adrian T. Kress, Robert J. Nadeau, Daniel J. Selig, Diana Caridha, Ratanachat Racharaks, Thomas Langowski, Michael S. Madejczyk, Chance Carbaugh, David Saunders, Mark Widder, Jason De Meese, Patricia J. Lee, Jesse P. DeLuca

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Macrophage migration inhibitory factor predicts an unfavorable outcome after transarterial chemoembolization for hepatic malignancies by Theresa H. Wirtz, Sven H. Loosen, Max Schulze‐Hagen, Joao Gorgulho, Jennis Kandler, Markus Joerdens, Münevver Demir, Raphael Mohr, Philipp Bruners, Christiane Kuhl, Christian Trautwein, Marie‐Luise Berres, Frank Tacke, Tom Luedde, Christoph Roderburg

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Quantification of increased biologically active CXCL12α plasma concentrations after ACKR3 antagonist treatment in humans by Peter Blattmann, Hervé Farine, Brian Dan, Nicole Stiffler, Thomas Lefebvre, Christine Huynh, Patricia N. Sidharta, Jasper Dingemanse, Richard W. D. Welford, Marcel Keller, Daniel S. Strasser

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Pharmacokinetics, safety, and efficacy of cedirogant from phase I studies in healthy participants and patients with chronic plaque psoriasis by Mohamed‐Eslam F. Mohamed, Yuli Qian, Ronilda D'Cunha, Teresa Sligh, Laura K. Ferris, Ann Eldred, Gweneth F. Levy, Shuai Hao, Shashikanth Gannu, David G. Rizzo, Wei Liu, Sasha Jazayeri, Howard Sofen, Roberto Carcereri De Prati

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Effect of CSL112 (apolipoprotein A‐I [human]) on cholesterol efflux capacity in Japanese subjects: Findings from a phase I study and a cross‐study comparison by Bo Zheng, Shinya Goto, Regina Clementi, John Feaster, Danielle Duffy, Penelope Dalitz, Jolanta Airey, Serge Korjian, Michael A. Tortorici, John Roberts, C. Michael Gibson

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