Search Results - "translational science"

Rilzabrutinib, a reversible covalent Bruton's tyrosine kinase inhibitor: Absorption, metabolism, excretion, and absolute bioavailability in healthy participants by Sibel Ucpinar, Patrick F. Smith, Li Long, Fujun Li, Hui Yan, Jyoti Wadhwa, Katherine A. Chu, Jin Shu, Philip Nunn, Mengyao Li

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Investigation of pharmacokinetic drug interaction between clesacostat and DGAT2 inhibitor ervogastat in healthy adult participants by Aarti Sawant‐Basak, Arthur J. Bergman, Jessica Mancuso, Sakambari Tripathy, James R. Gosset, Laure Mendes da Costa, William P. Esler, Roberto A. Calle

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Clinical assessment of gepotidacin (GSK2140944) as a victim and perpetrator of drug-drug interactions via CYP3A metabolism and transporters by Aline Barth, Caroline R. Perry, Shaila Shabbir, Maciej J. Zamek‐Gliszczynski, Sebin Thomas, Etienne F. Dumont, Darin B. Brimhall, Dung Nguyen, Meenakshi Srinivasan, Brandon Swift

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Construction and evaluation of a risk prediction model for pulmonary infection‐associated acute kidney injury in intensive care units by Xinyi Cao, Yongzhi Liang, Honglin Feng, Li Chen, Shengming Liu

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Prognostic impact of pleural effusion in patients with malignancy: A systematic review and meta‐analysis by Yuan Yang, Juan Du, Yi‐Shan Wang, Han‐YuJie Kang, Kan Zhai, Huan‐Zhong Shi

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Safety, pharmacokinetics, and pharmacodynamics in healthy Chinese volunteers treated with SC0062, a highly selective endothelin‐A receptor antagonist by Yun Liu, Wei Wang, Hongjie Qian, Yuzhou Gui, Yating Wang, Rong Song, Qian Chen, Eric Rowinsky, Sheng Wang, Xiaoguang Liang, Kaicun Gu, Bo Zhou, Weiwei Zhang, Liqin Zhang, Chen Yu, Jingying Jia

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Generic substitution of amlodipine is not associated with increased risk of mortality or adverse cardiovascular events: An observational cohort study by Boya Zhao, Jing Wu, Chengzhi Lu, Xing Lin Feng

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Pharmacogenomics of celiprolol - evidence for a role of P‐glycoprotein and organic anion transporting polypeptide 1A2 in celiprolol pharmacokinetics by Päivi Hirvensalo, Aleksi Tornio, Tuija Tapaninen, Maria Paile‐Hyvärinen, Mikko Neuvonen, Janne T. Backman, Mikko Niemi

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Long‐term effects of average calcineurin inhibitor trough levels (over time) on renal function in a prospectively followed cohort of 150 kidney transplant recipients by Gaetano Ciancio, Jeffrey J. Gaynor, Giselle Guerra, Marina M. Tabbara, David Roth, Warren Kupin, Adela Mattiazzi, Lissett Moni, George W. Burke III

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Assessment of pharmacokinetics, safety, and tolerability following twice‐daily administration of molnupiravir for 10 days in healthy participants by Marian Iwamoto, Kelly E. Duncan, Prachi K. Wickremasingha, Tian Zhao, Maria V. Liberti, Lieselotte Lemoine, Tatjana Decaesteker, Sylvie Rottey, Brian M. Maas, Gillian Gillespie, S. Aubrey Stoch

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A Phase I, Randomized, Double‐Blind, Placebo‐Controlled, Single‐Dose and Multiple‐Rising‐Dose Study of the BTK Inhibitor TAK‐020 in Healthy Subjects by Ehsanollah Esfandiari, Mary Chen, Glennda Smithson, Derek Blair, Helene Faessel, John Wagner, Lachy Mclean, Eric R. Fedyk

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Dose‐dependent inactivation of airway tryptase with a novel dissociating anti‐tryptase antibody (MTPS9579A) in healthy participants: A randomized trial by Sharon M. Rymut, Siddharth Sukumaran, Gizette Sperinde, Meire Bremer, Joshua Galanter, Kenta Yoshida, Jordan Smith, Prajna Banerjee, Viyia Sverkos, Fang Cai, Verena Steffen, Lindsay M. Henderson, Horace Rhee, Paula N. Belloni, Joseph H. Lin, Tracy L. Staton

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Particle size affects pharmacokinetics of milled oxycodone hydrochloride tablet products following nasal insufflation in nondependent, recreational opioid users by Saeid Raofi, Minori Kinjo, Dajun Sun, Zhichuan Li, Heather Boyce, Karthika Natarajan, Mitchell Frost, Liang Zhao, Markham Luke, Robert Lionberger, Debra Kelsh, Myong‐Jin Kim

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A pharmacokinetic simulation study to assess the performance of a sparse blood sampling approach to quantify early drug exposure by Abhishek G. Sathe, Richard C. Brundage, Vijay Ivaturi, James C. Cloyd, James M. Chamberlain, Jordan J. Elm, Robert Silbergleit, Jaideep Kapur, Lisa D. Coles

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A phase I evaluation of the effect of curcumin on dose‐limiting toxicity and pharmacokinetics of irinotecan in participants with solid tumors by Olumide B. Gbolahan, Bert H. O'Neil, Autumn J. McRee, Hanna K. Sanoff, John K. Fallon, Philip C. Smith, Anastasia Ivanova, Dominic T. Moore, Julie Dumond, Gary N. Asher

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SMAD4 loss is associated with response to neoadjuvant chemotherapy plus hydroxychloroquine in patients with pancreatic adenocarcinoma by Naomi Fei, Sijin Wen, Rajesh Ramanathan, Melissa E. Hogg, Amer H. Zureikat, Michael T. Lotze, Nathan Bahary, Aatur D. Singhi, Herbert J. Zeh, Brian A. Boone

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Effect of food on capsule and granule formulations of selumetinib by Sarit Cohen‐Rabbie, Alexandra Mattinson, Karen So, Nan Wang, Ronald Goldwater

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Prevalence and prescribing patterns of oral corticosteroids in the United States, Taiwan, and Denmark, 2009-2018 by Beth I. Wallace, Hui‐Ju Tsai, Paul Lin, Kristian Aasbjerg, Ann Chen Wu, Yi‐Fen Tsai, Christian Torp‐Pedersen, Akbar K. Waljee, Tsung‐Chieh Yao

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Clinical evaluation of large volume subcutaneous injection tissue effects, pain, and acceptability in healthy adults by Wendy D. Woodley, Didier R. Morel, Diane E. Sutter, Ronald J. Pettis, Natasha G. Bolick

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Randomized, placebo‐controlled study on the effects of intravenous GSK3858279 (anti‐CCL17) on a battery of evoked pain tests in healthy participants by Yvonne Boyle, Hemme J. Hijma, Jamie Rees, Jagtar Nijjar, Eirini Panoilia, Yolanda Alvarez, Sarah Siederer, Emma Greening, Edward Emery, Kathy Abbott Banner, Geert Jan Groeneveld

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