Search Results - "translational science"

Prospective evaluation of high‐dose methotrexate pharmacokinetics in adult patients with lymphoma using novel determinants of kidney function by Jason N. Barreto, Joel M. Reid, Carrie A. Thompson, Kristin C. Mara, Andrew D. Rule, Kianoush B. Kashani, Nelson Leung, Thomas R. Larson, Renee M. McGovern, Thomas E. Witzig, Erin F. Barreto

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Evaluation of levocetirizine in beagle dog and cynomolgus monkey telemetry assays: Defining the no QTc effect profile by timepoint and concentration‐QTc analysis by Michael J. Engwall, Joel Baublits, Fiona A. Chandra, Zack W. Jones, Jan Wahlstrom, Ray W. Chui, Hugo M. Vargas

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New insight of chemical constituents in Persea americana fruit against obesity via integrated pharmacology by Min‐Gi Cha, Su‐Been Lee, Sang‐Jun Yoon, Sang Youn Lee, Haripriya Gupta, Raja Ganesan, Satya Priya Sharma, Sung‐Min Won, Jin‐Ju Jeong, Dong Joon Kim, Ki‐Kwang Oh, Ki‐Tae Suk

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Comparison of variants in TPMT and NUDT15 between sequencing and genotyping methods in a multistate pediatric institution by Kelsey J. Cook, Victoria Grusauskas, Lucy Gloe, Benjamin Q. Duong, Renee C. Gresh, E. Anders Kolb, Manisha Bansal, Allison S. Bechtel, Ramamoorthy Nagasubramanian, Susan M. Kirwin, Kathryn V. Blake, Nathan D. Seligson

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A randomized, multicenter trial assessing the effects of rapastinel compared to ketamine, alprazolam, and placebo on simulated driving performance by Shengfang Su, Gary Kay, Thomas Hochadel, Jonathan Rojo, J. Christopher Stein, Ramesh Boinpally, Antonia Periclou

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Pharmacometabonomic association of cyclophosphamide 4‐hydroxylation in hematopoietic cell transplant recipients by Jeannine S. McCune, Ryotaro Nakamura, Denis O'Meally, Timothy W. Randolph, Brenda M. Sandmaier, Aleksandra Karolak, David Hockenbery, Sandi L. Navarro

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Clinical evaluation of PF614, a novel TAAP prodrug of oxycodone, versus OxyContin in a multi‐ascending dose study with a bioequivalence arm in healthy volunteers by D. Lynn Kirkpatrick, Cari Evans, Linda A. Pestano, Jeffrey Millard, Matthew Johnston, Emily Mick, William K. Schmidt

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Remote Digital Monitoring for Medical Product Development by Elena S. Izmailova, John A. Wagner, Nadir Ammour, Ninad Amondikar, Andrea Bell‐Vlasov, Steven Berman, Dan Bloomfield, Linda S. Brady, Xuemei Cai, Roberto A. Calle, Michelle Campbell, Francesca Cerreta, Ieuan Clay, Luca Foschini, Pat Furlong, Rob Goldel, Jennifer S. Goldsack, Peter M.A. Groenen, Amos Folarin, Jill Heemskerk, Peter Honig, Matthew Hotopf, Tania Kamphaus, Daniel R. Karlin, Christopher Leptak, Qi Liu, Husseini Manji, Robert J. Mather, Joseph P. Menetski, Vaibhav A. Narayan, Elektra Papadopoulos, Bakul Patel, Bray Patrick‐Lake, Jagdeep T. Podichetty, Abhishek Pratap, Laurent Servais, Diane Stephenson, Pam Tenaerts, Bruce J. Tromberg, Steve Usdin, Srikanth Vasudevan, Vadim Zipunnikov, Steven C. Hoffmann

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High mobility group box 1, ATP, lipid mediators, and tissue factor are elevated in COVID‐19 patients: HMGB1 as a biomarker of worst prognosis by Amanda Roberta Revoredo Vicentino, Vanderlei da Silva Fraga‐Junior, Matheus Palazzo, Natalia Recardo Amorim Tasmo, Danielle A. S. Rodrigues, Shana Priscila Coutinho Barroso, Sâmila Natiane Ferreira, Anna Cristina Neves‐Borges, Diego Allonso, Marcelo Rosado Fantappié, Julio Scharfstein, Ana Carolina Oliveira, Rosane Vianna‐Jorge, André Macedo Vale, Robson Coutinho‐Silva, Luiz Eduardo Baggio Savio, Claudio Canetti, Claudia Farias Benjamim

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Population pharmacokinetics of intramuscular recombinant Erwinia chrysanthemi asparaginase (JZP458) in patients with acute lymphoblastic leukemia by Tong Lin, Tajhia Whigham, Indrasiri Fernando, Mi Rim Choi, Qi Wang, Jeffrey A. Silverman

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Proposing a framework to quantify the potential impact of pharmacokinetic drug-drug interactions caused by a new drug candidate by using real world data about the target patient po... by Simon Dagenais, Christine Lee, Carol Cronenberger, Ellen Wang, Vaishali Sahasrabudhe

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Population pharmacokinetics and CD20 binding dynamics for mosunetuzumab in relapsed/refractory B‐cell non‐Hodgkin lymphoma by Brendan Bender, Chi‐Chung Li, Mathilde Marchand, David C. Turner, Feifei Li, Shweta Vadhavkar, Bei Wang, Rong Deng, James Lu, Jin Jin, Chunze Li, Shen Yin, Michael Wei, Pascal Chanu

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Pre- and postmarathon training habits of nonelite runners by Angela M Voight, William O Roberts, Scott Lunos, et al

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Phase I crossover study of DNA‐protein kinase inhibitor peposertib in healthy volunteers: Effect of food and pharmacokinetics of an oral suspension by Andreas Becker, Axel Krebs‐Brown, Claudia Vetter, Tanja Reuter, Almudena Rodriguez‐Gutierrez, Xiaoli You, Michael Lissy

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High intrapatient variability of tacrolimus exposure associated with poorer outcomes in liver transplantation by Cristina Dopazo, Itxarone Bilbao, Sonia García, Concepción Gómez‐Gavara, Mireia Caralt, Isabel Campos‐Varela, Lluis Castells, Ernest Hidalgo, Francisco Moreso, Bruno Montoro, Ramón Charco

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A leucine‐rich repeat kinase 2 (LRRK2) pathway biomarker characterization study in patients with Parkinson's disease with and without LRRK2 mutations and healthy controls by Maurits F. J. M. Vissers, Matthew D. Troyer, Eva Thijssen, Diana R. Pereira, | Jules A. A. C. Heuberger, Geert Jan Groeneveld, Sarah Huntwork‐Rodriguez

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Characterization of CYP3A pharmacogenetic variation in American Indian and Alaska Native communities, targeting CYP3A4*1G allele function by Alison E. Fohner, Rachel Dalton, Kasse Skagen, Konner Jackson, Katrina G. Claw, Scarlett E. Hopkins, Renee Robinson, Burhan A. Khan, Bhagwat Prasad, Erin G. Schuetz, Deborah A. Nickerson, Timothy A. Thornton, Denise A. Dillard, Bert B. Boyer, Kenneth E. Thummel, Erica L. Woodahl

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Cardiovascular events and safety outcomes associated with remdesivir using a World Health Organization international pharmacovigilance database by Se Yong Jung, Min Seo Kim, Han Li, Keum Hwa Lee, Ai Koyanagi, Marco Solmi, Andreas Kronbichler, Elena Dragioti, Kalthoum Tizaoui, Sarah Cargnin, Salvatore Terrazzino, Sung Hwi Hong, Ramy Abou Ghayda, Nam Kyun Kim, Seo Kyoung Chung, Louis Jacob, Joe‐Elie Salem, Dong Keon Yon, Seung Won Lee, Karel Kostev, Ah Young Kim, Jo Won Jung, Jae Young Choi, Jin Soo Shin, Soon‐Jung Park, Seong Woo Choi, Kiwon Ban, Sung‐Hwan Moon, Yun Young Go, Jae Il Shin, Lee Smith

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Impact of type 2 diabetes on in vivo activities and protein expressions of cytochrome P450 in patients with obesity by Kine Eide Kvitne, Anders Åsberg, Line K. Johnson, Christine Wegler, Jens K. Hertel, Per Artursson, Cecilia Karlsson, Shalini Andersson, Rune Sandbu, Eva Skovlund, Hege Christensen, Rasmus Jansson‐Löfmark, Jøran Hjelmesæth, Ida Robertsen

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First‐in‐human study of JNJ‐67571244, a CD33 × CD3 bispecific antibody, in relapsed/refractory acute myeloid leukemia and myelodysplastic syndrome by Rupa Narayan, Ana Alfonso Piérola, William B. Donnellan, Antonieta Molero Yordi, Maher Abdul‐Hay, Uwe Platzbecker, Marion Subklewe, Tapan Mahendra Kadia, Juan Manuel Alonso‐Domínguez, James McCloskey, Kathryn Bradford, Martin Curtis, Nikki Daskalakis, Christina Guttke, Karim Safer, Brett Hiebert, Joseph Murphy, Xiang Li, Ken Duchin, Daniel Esteban

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