Search Results - "translational science"

Pharmacokinetics and safety of mavacamten in healthy Chinese participants with different CYP2C19 phenotypes by Xiaojie Wu, Nanye Chen, Peiwen Hsu, Jing Sun, Wenting Li, Qi Wang, Merali Samira, Qiong Wei, Jicheng Yu, Guoying Cao, Haijing Yang, Lili Wang, Jingjing Wang, Yi Jin, Wei Liu, Jufang Wu, Jinjie He, Cheng Lyu, Jing Zhang

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Effect of AZD9977 and spironolactone on serum potassium in heart failure with preserved or mildly reduced ejection fraction, and renal impairment: A randomized trial by Iain B. Squire, Anders Gabrielsen, Peter J. Greasley, Linda Wernevik, Judith Hartleib‐Geschwindner, Julie Holden, Susanne Johansson, Anna Rudvik, José Sánchez, Krister Bamberg, Johanna Melin, Andrew Whittaker

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First‐in‐human study of JNJ‐63709178, a CD123/CD3 targeting antibody, in relapsed/refractory acute myeloid leukemia by Michael Boyiadzis, Pinkal Desai, Nikki Daskalakis, William Donnellan, Lucille Ferrante, Jenna D. Goldberg, Michael R. Grunwald, Christina Guttke, Xiang Li, Jose Antonio Perez‐Simon, Olga Salamero, Trevor Tucker, Xiaoying Xu, Jay Yang, Naveen Pemmaraju, Juan Manuel Alonso‐Dominguez

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Vitamin D and the immunomodulation of rotator cuff injury by Dougherty KA, Dilisio MF, Agrawal DK

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Physiologically‐based pharmacokinetic model‐based translation of OATP1B‐mediated drug-drug interactions from coproporphyrin I to probe drugs by Tatsuki Mochizuki, Yasunori Aoki, Takashi Yoshikado, Kenta Yoshida, Yurong Lai, Hideki Hirabayashi, Yoshiyuki Yamaura, Kevin Rockich, Kunal Taskar, Tadayuki Takashima, Xiaoyan Chu, Maciej J. Zamek‐Gliszczynski, Jialin Mao, Kazuya Maeda, Kenichi Furihata, Yuichi Sugiyama, Hiroyuki Kusuhara

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Managing endothelial dysfunction in COVID‐19 with statins, beta blockers, nicorandil, and oral supplements: A pilot, double‐blind, placebo‐controlled, randomized clinical trial... by Kamal Matli, Abdulrahman Al Kotob, Wassim Jamaleddine, Soad Al Osta, Pascale Salameh, Rami Tabbikha, Nibal Chamoun, Ahmad Moussawi, Jean‐Michel Saad, Gibran Atwi, Tarik Abu Saad, Omar Jamal, Jacques Mokhbat, Georges Ghanem

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Substantially Increased Plasma Coproporphyrin‐I Concentrations Associated With OATP1B1*15 Allele in Japanese General Population by Yosuke Suzuki, Yuri Sasamoto, Teruhide Koyama, Chisato Yoshijima, Masahiro Nakatochi, Michiaki Kubo, Yukihide Momozawa, Ritei Uehara, Keiko Ohno

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The effect of age on blood pressure response by 4‐week treatment perindopril: A pooled sex‐specific analysis of the EUROPA, PROGRESS, and ADVANCE trials by Michelle M. Schreuder, Katrina M. Mirabito Colafella, Eric Boersma, Jasper J. Brugts, Jeanine E. Roeters van Lennep, Jorie Versmissen

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Impact of CYP2D6 and CYP2B6 phenotypes on the response to tramadol in patients with acute post‐surgical pain by Ana Casajús, Pablo Zubiaur, Enrique Alday, Paula Soria‐Chacartegui, Miriam Saiz‐Rodríguez, Lara Gutierrez, Catalina Aragonés, Diana Campodónico, Antía Gómez‐Fernández, Marcos Navares‐Gómez, Gonzalo Villapalos‐García, Gina Mejía‐Abril, Dolores Ochoa, Francisco Abad‐Santos

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Performance of Plasma Adenosine as a Biomarker for Predicting Cardiovascular Risk by Trevor Simard, Richard G. Jung, Pietro Di Santo, F. Daniel Ramirez, Alisha Labinaz, Chantal Gaudet, Pouya Motazedian, Simon Parlow, Joanne Joseph, Robert Moreland, Jeffrey Marbach, Paul Boland, Steven Promislow, Juan J. Russo, Aun‐Yeong Chong, Derek So, Michael Froeschl, Michel Le May, Benjamin Hibbert

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Factors influencing the presence of potentially explosive gases during colonoscopy: Results of the SATISFACTION study by Marino Carnovali, Cristiano Spada, Peter Uebel, Paolo Bocus, Renato Cannizzaro, Flaminia Cavallaro, Bruno Mario Cesana, Paola Cesaro, Guido Costamagna, Dhanai Di Paolo, Angelo Paulo Ferrari, Carsten Hinkel, Sergey Kashin, Arianna Massella, Ekaterina Melnikova, Anna Orsatti, Thierry Ponchon, Alberto Prada, Franco Radaelli, Sandro Sferrazza, Pietro Soru, Pier Alberto Testoni, Gian Eugenio Tontini, Maurizio Vecchi, Giancarla Fiori, the SATISFACTION Study Group

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Effect of Rifampin‐Mediated OATP1B1 and OATP1B3 Transporter Inhibition on the Pharmacokinetics of the P2Y12 Receptor Antagonist Selatogrel by Uta Schilling, Jasper Dingemanse, Christine Voors‐Pette, Christel Romeijn, Peter Dogterom, Mike Ufer

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Implementing a pragmatic clinical trial to tailor opioids for chronic pain on behalf of the IGNITE ADOPT PGx investigators by Todd C. Skaar, Rachel A. Myers, Roger B. Fillingim, John T. Callaghan, Emily Cicali, Michael T. Eadon, Erica N. Elwood, Geoffrey S. Ginsburg, Sheryl Lynch, Khoa A. Nguyen, Aniwaa Owusu Obeng, Haesuk Park, Victoria M. Pratt, Marc Rosenman, Azita Sadeghpour, Saskia Shuman, Rajbir Singh, Emma M. Tillman, Simona Volpi, Kristin Wiisanen, Almut G. Winterstein, Carol R. Horowitz, Deepak Voora, Lori Orlando, Hrishikesh Chakraborty, Sara Van Driest, Josh F. Peterson, Larisa A. Cavallari, Julie A. Johnson, Paul R. Dexter, the IGNITE Pragmatic Trials Network

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Regulatory variants in a novel distal enhancer regulate the expression of CYP3A4 and CYP3A5 by Joseph M. Collins, Adaeze C. Nworu, Somayya J. Mohammad, Liang Li, Chengcheng Li, Chuanjiang Li, Ethan Schwendeman, Mattew Cefalu, Mahmoud Abdel‐Rasoul, Jessie W. Sun, Sakima A. Smith, Danxin Wang

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MIJ821 (onfasprodil) in healthy volunteers: First‐in‐human, randomized, placebo‐controlled study (single ascending dose and repeated intravenous dose) by Baltazar Gomez‐Mancilla, Jeffrey A. Levy, Subramanian Ganesan, Thomas Faller, Gil Issachar, Ziv Peremen, Offir Laufer, Revital Shani‐Hershkovich, Kostas Biliouris, Ela Walker, Mark P. Healy, Oleksandr Sverdlov, Sachin Desai, S. Nassir Ghaemi, Jang‐Ho Cha, Y. Gopi Shanker

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Pharmacokinetics of dacarbazine and unesbulin and CYP1A2‐mediated drug interactions in patients with leiomyosarcoma by Lan Gao, Diksha Kaushik, Brian A. Van Tine, Matthew A. Ingham, Steven Attia, Christian F. Meyer, Gary K. Schwartz, Pius Maliakal, John D. Baird, Jiyuan Ma, Rosemary Barrett, Dhiren D'Silva, Kylie O'Keefe, Ronald Kong

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Evidence of depot‐specific regulation of all‐trans‐retinoic acid biosynthesis in human adipose tissue by Katya B. Rubinow, Guo Zhong, Lindsay C. Czuba, Judy Y. Chen, Estell Williams, Zoe Parr, Saurabh Khandelwal, Daniel Kim, Jeffrey LaFrance, Nina Isoherranen

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β1‐receptor polymorphisms and junctional ectopic tachycardia in children after cardiac surgery by Leanne Dumeny, Marut Chantra, Taimour Langaee, Benjamin Q. Duong, Daniel H. Zambrano, Frank Han, Dalia Lopez‐Colon, James F. Humma, Jonathan Dacosta, Tommie Lovato, Connie Mei, Julio D. Duarte, Julie A. Johnson, Giles J. Peek, Jeffrey P. Jacobs, Mark S. Bleiweis, Larisa H. Cavallari

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Differences of adrenal‐derived androgens in 5α‐reductase deficiency versus androgen insensitivity syndrome by Bing Han, Hui Zhu, Haijun Yao, Jianwei Ren, Patrick O'Day, Hao Wang, Wenjiao Zhu, Tong Cheng, Richard J. Auchus, Jie Qiao

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Bioavailability of three novel oral, sustained‐release pellets, relative to an immediate‐release tablet containing 500 mg flucytosine: A randomized, open‐label, crossover study in... by Vishal Goyal, Edrich Krantz, Francois Simon, Anouk Neven, Johanna Eriksson, Amaria Saayman, Nabila Ibnou Zekri Lassout, Mathieu Louis, Stephen Robinson, Abhijit Deshmukh, Amit Antarkar, Carol Ruffell, Sarika Victor, Marylore Chenel, Aljosa Celebic, Henri Caplain, Jean‐Yves Gillon, Isabela Ribeiro

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