Search Results - "translational science"

First‐in‐human phase 1 trial evaluating safety, pharmacokinetics, and pharmacodynamics of NLRP3 inflammasome inhibitor, GDC‐2394, in healthy volunteers by Fei Tang, Rebecca Kunder, Tom Chu, Avis Hains, Allen Nguyen, Jacqueline M. McBride, Yu Zhong, Sara Santagostino, Maria Wilson, Abigail Trenchak, Liuxi Chen, Justin Ly, Anita Moein, Nicholas Lewin‐Koh, Vibha Raghavan, Uyi Osaghae, Chris Wynne, Ryan Owen, David Place

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Precision Antiplatelet Therapy after Percutaneous Coronary Intervention (Precision PCI) Registry - Informing optimal antiplatelet strategies by Larisa H. Cavallari, Craig R. Lee, Francesco Franchi, Ellen C. Keeley, Joseph S. Rossi, Cameron D. Thomas, Yan Gong, Caitrin W. McDonough, Petr Starostik, Maryam J. Al Saeed, Latonya Been, Natasha Kulick, Jean Malave, Ian R. Mulrenin, Anh B. Nguyen, Joshua N. Terrell, Grace Tillotson, Amber L. Beitelshees, Almut G. Winterstein, George A. Stouffer, Dominick J. Angiolillo

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Comparative effectiveness and safety of extended anticoagulant therapy among Medicare beneficiaries with venous thromboembolism by Haesuk Park, Hye‐Rim Kang, Pei‐Lin Huang, Wei‐Hsuan Lo‐Ciganic, Christina E. DeRemer, Debbie Wilson, Eric A. Dietrich

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Pharmacokinetics of vaginal versus buccal misoprostol for labor induction at term by Yana Vorontsova, David M. Haas, Kathleen Flannery, Andrea R. Masters, Larissa L. Silva, Rebecca C. Pierson, Brittany Yeley, Graham Hogg, David Guise, Michael Heathman, Sara K. Quinney

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Relationship between blood glucose levels and length of hospital stay in patients with acute pancreatitis: An analysis of MIMIC‐III database by Dongyan Wang, Jie Lu, Pan Zhang, Zhengyu Hu, Yihai Shi

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Pharmacokinetic equivalence of CT‐P17 to high‐concentration (100 mg/ml) reference adalimumab: A randomized phase I study in healthy subjects by Kyung‐Sang Yu, In‐Jin Jang, Hyeong‐Seok Lim, Jang Hee Hong, Min‐Gul Kim, Min Kyu Park, Doo‐Yeoun Cho, Min Soo Park, Jae Yong Chung, Jong‐Lyul Ghim, SeungHwan Lee, Seok Kyu Yoon, In Sun Kwon, Sang Joon Lee, Sung Hyun Kim, Yun Ju Bae, Jung Bin Cha, Daniel E. Furst, Edward Keystone, Jonathan Kay

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Pharmacokinetics of apixaban and tacrolimus or cyclosporine in kidney and lung transplant recipients by Holly Mansell, Ahmed Shoker, Jane Alcorn, Mark E. Fenton, Julian S. Tam, William Semchuk, Babar Bashir, Walter K. Kraft, Shenzhen Yao, James D. Douketis

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Evaluation of drug‐drug interaction potential between omecamtiv mecarbil and rosuvastatin, a BCRP substrate, with a clinical study in healthy subjects and using a physiologically‐b... by Ashit Trivedi, Winnie Sohn, Priyanka Kulkarni, Pegah Jafarinasabian, Hanze Zhang, Marintan Spring, Stephen Flach, Siddique Abbasi, Jan Wahlstrom, Edward Lee, Sandeep Dutta

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Coproporphyrin I Can Serve as an Endogenous Biomarker for OATP1B1 Inhibition: Assessment Using a Glecaprevir/Pibrentasvir Clinical Study by Hari V. Kalluri, Ryota Kikuchi, Sheryl Coppola, Jeffrey Schmidt, Mohamed‐Eslam F. Mohamed, Daniel A.J. Bow, Ahmed H. Salem

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Multisite evaluation of institutional processes and implementation determinants for pharmacogenetic testing to guide antidepressant therapy by Sony Tuteja, Ramzi G. Salloum, Amanda L. Elchynski, D. Max Smith, Elizabeth Rowe, Kathryn V. Blake, Nita A. Limdi, Christina L. Aquilante, Jill Bates, Amber L. Beitelshees, Amber Cipriani, Benjamin Q. Duong, Philip E. Empey, Christine M. Formea, J. Kevin Hicks, Pawel Mroz, David Oslin, Amy L. Pasternak, Natasha Petry, Laura B. Ramsey, Allyson Schlichte, Sandra M. Swain, Kristen M. Ward, Kristin Wiisanen, Todd C. Skaar, Sara L. Van Driest, Larisa H. Cavallari, Jeffrey R. Bishop, for the IGNITE Pharmacogenetics Working Group

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Short‐ and long‐term effects of body weight loss following calorie restriction and gastric bypass on CYP3A‐activity - a non‐randomized three‐armed controlled trial by Kine Eide Kvitne, Ida Robertsen, Eva Skovlund, Hege Christensen, Veronica Krogstad, Christine Wegler, Philip Carlo Angeles, Birgit Malene Wollmann, Kristine Hole, Line Kristin Johnson, Rune Sandbu, Per Artursson, Cecilia Karlsson, Shalini Andersson, Tommy B. Andersson, Jøran Hjelmesæth, Rasmus Jansson‐Löfmark, Anders Åsberg

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Factors influencing new‐onset hypertension in elderly patients with obstructive sleep apnea: A multicenter cohort study by LiBo Zhao, YingHui Gao, WeiHao Xu, KaiLiang Li, Lin Liu, Li Fan

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The anti‐C5a antibody vilobelimab efficiently inhibits C5a in patients with severe COVID‐19 by Alexander P. J. Vlaar, Endry H. T. Lim, Sanne deBruin, Simon Rückinger, Korinna Pilz, Matthijs C. Brouwer, Ren‐Feng Guo, Leo M. A. Heunks, Matthias H. Busch, Pieter vanPaassen, Niels C. Riedemann, Diederik van deBeek

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Pharmacokinetics of Sofosbuvir/Velpatasvir and efficacy of an alternate‐day treatment in hemodialysis patients with chronic hepatitis C infection by Pajaree Chariyavilaskul, Nantaporn Prompila, Supeecha Wittayalertpanya, Sookruethai Lekhyananda, Wisit Prasithsirikul, Thananda Trakarnvanich, Somboon Jeenapongsa, Paweena Susantitaphong, Stephen Kerr, Anchalee Avihingsanon, Pisit Tangkijvanich, Kearkiat Praditpornsilpa

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Translational findings for odronextamab: From preclinical research to a first‐in‐human study in patients with CD20+ B‐cell malignancies by Min Zhu, Kara Olson, Jessica R. Kirshner, Masood Khaksar Toroghi, Hong Yan, Lauric Haber, Craig Meagher, Dina M. Flink, Srikanth R. Ambati, John D. Davis, A. Thomas DiCioccio, Eric J. Smith, Marc W. Retter

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Clinical differences in sirolimus treatment with low target levels between children and adults with vascular malformations - A nationwide trial by Veroniek E. M. Harbers, Lilly G. J. M. Zwerink, Gerard A. Rongen, Willemijn M. Klein, Carine J. M. van derVleuten, Ingrid M. P. vanRijnsoever, Lynda Gerdsen‐Drury, Uta E. Flucke, Bas H. Verhoeven, Peter C. J. deLaat, Chantal M. A. M. van derHorst, Leo J. Schultze Kool, D. Maroeska W. M. teLoo

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AZD9567 versus prednisolone in patients with active rheumatoid arthritis: A phase IIa, randomized, double‐blind, efficacy, and safety study by Jacob M. vanLaar, Alejhandra Lei, Mary Safy‐Khan, Joachim Almquist, Graham Belfield, Karl Edman, Lisa Öberg, Bastian R. Angermann, Inken Dillmann, Pia Berntsson, Damla Etal, Ian Dainty, Carol Astbury, Maria G. Belvisi, Szilárd Nemes, Adam Platt, Susanne Prothon, Sara Samuelsson, Petter Svanberg, Christina Keen, the SEMRA study group

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Treatment outcomes of secukinumab in adult patients with moderate‐to‐severe plaque psoriasis in China: A real‐world multicenter retrospective study by Yangfeng Ding, Wei Li, Xin Guan, Na Liu, Ying Zhou, Gaojie Li, Xiaohua Wang, Zhidong Wang, Xiao Xiao, Bin Yang, Chengzhi Lv, Chunlei Zhang, Yuling Shi

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Posaconazole and midostaurin in patients with FLT3‐mutated acute myeloid leukemia: Pharmacokinetic interactions and clinical facts in a real life study by Pierantonio Menna, Francesco Marchesi, Chiara Cattaneo, Anna Candoni, Mario Delia, Gianpaolo Nadali, Alessandra Vatteroni, Crescenza Pasciolla, Salvatore Perrone, Luisa Verga, Daniele Armiento, Maria Ilaria Del Principe, Nicola S. Fracchiolla, Emanuela Salvatorelli, Santina Lupisella, Irene Terrenato, Alessandro Busca, Giorgio Minotti, Livio Pagano

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Applicability of ancestral genotyping in pharmacogenomic research with hormonal contraception by Aaron Lazorwitz, Christina L. Aquilante, Jonathan A. Shortt, Jeanelle Sheeder, Stephanie Teal, Christopher R. Gignoux

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