Search Results - "translational science"

Thai pharmacogenomics database −2 (TPGxD‐2) sequel to TPGxD‐1, analyzing genetic variants in 26 non‐VIPGx genes within the Thai population by Shobana John, Sommon Klumsathian, Paravee Own‐eium, Angkana Charoenyingwattana, Jakris Eu‐ahsunthornwattana, Thanyachai Sura, Donniphat Dejsuphong, Piyamitr Sritara, Prin Vathesatogkit, Nartthawee Thongchompoo, Wiphaporn Thabthimthong, Nuttinee Teerakulkittipong, Wasun Chantratita, Chonlaphat Sukasem

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Free heme and hemopexin in acute kidney injury after cardiopulmonary bypass and transient renal ischemia by Robert Greite, Sebastian Schott, Li Wang, Lukas Gohlke, Kirill Kreimann, Katja Derlin, Marcel Gutberlet, Martina Schmidbauer, Andreas Leffler, Igor Tudorache, Jawad Salman, Fabio Ius, Ruslan Natanov, Christine Fegbeutel, Axel Haverich, Ralf Lichtinghagen, Anne M. Hüsing, Sibylle vonVietinghoff, Roland Schmitt, Nelli Shushakova, Song Rong, Hermann Haller, Kai M. Schmidt‐Ott, Magnus Gram, Vijith Vijayan, Irina Scheffner, Wilfried Gwinner, Stephan Immenschuh

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Diagnostic and prognostic capabilities of a biomarker and EMR‐based machine learning algorithm for sepsis by Ishan Taneja, Gregory L. Damhorst, Carlos Lopez‐Espina, Sihai Dave Zhao, Ruoqing Zhu, Shah Khan, Karen White, James Kumar, Andrew Vincent, Leon Yeh, Shirin Majdizadeh, William Weir, Scott Isbell, James Skinner, Manubolo Devanand, Syed Azharuddin, Rajamurugan Meenakshisundaram, Riddhi Upadhyay, Anwaruddin Syed, Thomas Bauman, Joseph Devito, Charles Heinzmann, Gregory Podolej, Lanxin Shen, Sanjay Sharma Timilsina, Lucas Quinlan, Setareh Manafirasi, Enrique Valera, Bobby Reddy Jr, Rashid Bashir

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Tissue pharmacokinetics of DHP107, a novel lipid‐based oral formulation of paclitaxel, in mice and patients by positron emission tomography by Byung Seok Moon, Hyun Soo Park, Jung Sunwoo, In‐Hyun Lee, Anhye Kim, Seol Ju Moon, Heechan Lee, Min Hee Son, Su Bin Kim, Sun Mi Park, Sang‐Keun Woo, Jun‐Hee Jang, Bom Sahn Kim, Jee Hyun Kim, Sang Eun Kim, Howard Lee

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Relationship of plasma 3‐carboxy‐4‐methyl‐5‐propyl‐2‐furanpropanoic acid concentration with OATP1B activity in patients with chronic kidney disease by Hiroyuki Ono, Ryota Tanaka, Yosuke Suzuki, Ayako Oda, Haruki Sato, Ryosuke Tatsuta, Tadasuke Ando, Toshitaka Shin, Keiko Ohno, Hiroki Itoh

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Effect of the NFIB rs28379954 T>C polymorphism on CYP2D6‐catalyzed metabolism of solanidine by Robert Løvsletten Smith, Birgit M. Wollmann, Elisabet Størset, Hasan Çağın Lenk, Kevin S. O'Connell, Marianne Kringen Kristiansen, Magnus Ingelman‐Sundberg, Espen Molden

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Evaluation of the usefulness of plasma 4β‐hydroxycholesterol concentration normalized by 4α‐hydroxycholesterol for accurate CYP3A phenotyping by Ayako Oda, Yosuke Suzuki, Haruki Sato, Teruhide Koyama, Masahiro Nakatochi, Yukihide Momozawa, Ryota Tanaka, Hiroyuki Ono, Ryosuke Tatsuta, Tadasuke Ando, Toshitaka Shin, Kenji Wakai, Keitaro Matsuo, Hiroki Itoh, Keiko Ohno

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Effect of cenobamate on the single‐dose pharmacokinetics of multiple cytochrome P450 probes using a cocktail approach in healthy subjects by Stephen A. Greene, Charles Kwak, Marc Kamin, Laurent Vernillet, Kelli J. Glenn, Lana Gabriel, Hong Wook Kim

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Pharmacogenomic polygenic risk score for clopidogrel responsiveness among Caribbean Hispanics: A candidate gene approach by Jorge Duconge, Ednalise Santiago, Dagmar F. Hernandez‐Suarez, Mariangeli Moneró, Andrés López‐Reyes, Marines Rosario, Jessicca Y. Renta, Pablo González, Laura Ileana Fernández‐Morales, Luis Antonio Vélez‐Figueroa, Orlando Arce, Frances Marín‐Maldonado, Héctor Nuñez, Kyle Melin, Stuart A. Scott, Gualberto Ruaño

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Rademikibart (CBP‐201), a next‐generation monoclonal antibody targeting human IL‐4Rα: Two phase I randomized trials, in healthy individuals and patients with atopic dermatitis... by Junying Wang, Jeffery White, Kenneth J. Sansone, Lynda Spelman, Rodney Sinclair, Xin Yang, Wubin Pan, Zheng Wei

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Study of the ketohexokinase inhibitor PF‐06835919 as a clinical cytochrome P450 3A inducer: Integrated use of oral midazolam and liquid biopsy by Ruolun Qiu, Kari Fonseca, Arthur Bergman, Jian Lin, David Tess, Lauren Newman, Alia Fahmy, Zivile Useckaite, Andrew Rowland, Manoli Vourvahis, David Rodrigues

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Tacrolimus pharmacokinetics are influenced by CYP3A5, age, and concomitant fluconazole in pediatric kidney transplant patients by Alaa Alghamdi, Sarah Seay, David K. Hooper, Charles D. Varnell Jr, Leanna Darland, Tomoyuki Mizuno, Danielle Lazear, Laura B. Ramsey

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Comparison of P‐glycoprotein function in peripheral blood mononuclear cells ex vivo in stable Black and White male and female kidney transplant recipients by Kathleen M. Tornatore, Kris Attwood, Daniel Brazeau, Jason Sprowl, Shirley Chang, Aijaz Gundroo, Hans Minderman, Rocco C. Venuto

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COVID‐19 and Immunological Dysregulation: Can Autoantibodies be Useful? by Simona Pascolini, Antonio Vannini, Gaia Deleonardi, Michele Ciordinik, Annamaria Sensoli, Ilaria Carletti, Lorenza Veronesi, Chiara Ricci, Alessia Pronesti, Laura Mazzanti, Ana Grondona, Tania Silvestri, Stefano Zanuso, Marcello Mazzolini, Claudine Lalanne, Chiara Quarneti, Marco Fusconi, Fabrizio Giostra, Alessandro Granito, Luigi Muratori, Marco Lenzi, Paolo Muratori

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Safety, pharmacokinetics, and pharmacodynamics of sofnobrutinib, a novel non‐covalent BTK inhibitor, in healthy subjects: First‐in‐human phase I study by Kyoko Miyamoto, Robert M. Miller, Christine Voors‐Pette, Jart A. F. Oosterhaven, Marieke van denDobbelsteen, Katsuhiro Mihara, Marian Geldof, Yuji Sato, Naomi Matsuda, Shirou Kirita, Masaaki Sawa, Akinori Arimura

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The development of a clinical research educational training for community health workers using the joint task force for clinical trial competency framework by Amin Yakubov, Amin Yakubov, Dina Pimenova, Alzahraa Ahmed, Romelia Corvacho, Joanna Madigan, Jay Naik, Chen Lyu, Anita McFarlane, Victoria Foster, Megan Haseltine, Alexandr Trifonov, Ivette Cabrera, Clarissa Rios, Rachel Gross, Melanie Jay, Aaron Lord, Gabrielle Gold-von Simson, Gabrielle Gold-von Simson, Brita Roy, Amy Freeman, Nadia Islam, Nadia Islam, James Holahan, James Holahan

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The effect of genetic variants in the transcription factor TSPYL family on the CYP3A4 mediated cyclosporine metabolism in kidney transplant patients by Qinglian Zhai, Dirk Jan A. R. Moes, Teun vanGelder, Maaike van derLee, Jan‐Stephan Sanders, Frederike J. Bemelman, Johan W. deFijter, Kathrin Klein, Matthias Schwab, Jesse J. Swen

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A phase I, randomized, ascending‐dose study to assess safety, pharmacokinetics, and activity of GDC‐8264, a RIP1 inhibitor, in healthy volunteers by Nicholas S. Jones, Smita Kshirsagar, Vishnu Mohanan, Vidya Ramakrishnan, Flavia Di Nucci, Ling Ma, Jialin Mao, Hao Ding, Sha Klabunde, Domagoj Vucic, Lin Pan, Annemarie N. Lekkerkerker, Yuan Chen, Michael E. Rothenberg

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Safety, Tolerability, Pharmacokinetics, Target Occupancy, and Concentration‐QT Analysis of the Novel BTK Inhibitor Evobrutinib in Healthy Volunteers by Andreas Becker, Emily C. Martin, David Y. Mitchell, Roland Grenningloh, Andrew T. Bender, Julien Laurent, Harald Mackenzie, Andreas Johne

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Bioavailability of a novel sustained‐release pellet formulation of 5‐flucytosine in healthy‐fed participants for use in patients with cryptococcal meningitis by Nabila Ibnou Zekri Lassout, Vishal Goyal, Edrich Krantz, Francois Simon, Anouk Neven, Johanna Eriksson, Amaria Saayman, Vijay Satam, Carol Ruffell, Sarika Victor, Marylore Chenel, Aljosa Celebic, Henri Caplain, Jean‐Yves Gillon, Abhijit Deshmukh, Amit Antarkar, Eric Sjögren, Isabela Ribeiro

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