Search Results - "translational science"

Predicted expression of genes involved in the thiopurine metabolic pathway and azathioprine discontinuation due to myelotoxicity by Laura L. Daniel, Alyson L. Dickson, Jacy T. Zanussi, Tyne W. Miller‐Fleming, Peter S. Straub, Wei‐Qi Wei, W. Dale Plummer, William D. Dupont, Ge Liu, Prathima Anandi, Tyler S. Reese, Kelly A. Birdwell, Vivian K. Kawai, Adriana M. Hung, Nancy J. Cox, QiPing Feng, C. Michael Stein, Cecilia P. Chung

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Enpatoran in COVID‐19 pneumonia: Safety and efficacy results from a phase II randomized trial by John E. McKinnon, Joel Santiaguel, Claudia Murta de Oliveira, Dongzi Yu, Mukhy Khursheed, Flavie Moreau, Lena Klopp‐Schulze, Jamie Shaw, Sanjeev Roy, Amy H. Kao, the ANEMONE Study Team

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Exposure‐response analysis for nivolumab plus ipilimumab combination therapy in patients with advanced hepatocellular carcinoma (CheckMate 040) by Bruno Sangro, Thomas Yau, Anthony B. El‐Khoueiry, Masatoshi Kudo, Yun Shen, Marina Tschaika, Amit Roy, Yan Feng, Ling Gao, Urvi Aras

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Safety and clinical efficacy of the double switch from originator infliximab to biosimilars CT‐P13 and SB2 in patients with inflammatory bowel diseases (SCESICS): A multicenter coh... by Stefano Mazza, Nicole Piazza O. Sed, Francesco Simone Conforti, Alberto Fascì, Alessandro Rimondi, Beatrice Marinoni, Valentina Casini, Chiara Ricci, Francesca Munari, Lorena Pirola, Pietro Invernizzi, Carlo Girelli, Guido Lupinacci, Luca Pastorelli, Flaminia Cavallaro, Luca Ferraris, Alice Colucci, Arnaldo Amato, Gian Eugenio Tontini, Maurizio Vecchi, Gionata Fiorino, Flavio Caprioli

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A comprehensive Thai pharmacogenomics database (TPGxD‐1): Phenotype prediction and variants identification in 942 whole‐genome sequencing data by Shobana John, Sommon Klumsathian, Paravee Own‐eium, Jakris Eu‐ahsunthornwattana, Thanyachai Sura, Donniphat Dejsuphong, Piyamitr Sritara, Prin Vathesatogkit, Nartthawee Thongchompoo, Wiphaporn Thabthimthong, Nuttinee Teerakulkittipong, Wasun Chantratita, Chonlaphat Sukasem

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A randomized, controlled, feasibility study of RD‐X19 in subjects with mild‐to‐moderate COVID‐19 in the outpatient setting by Nathan Stasko, Adam S. Cockrell, Jacob F. Kocher, Ibrahim Henson, David Emerson, Ye Wang, Jonathan R. Smith, Nathan H. Henderson, Hillary Wood, Shelton S. Bradrick, Terry Jones, Jorge Santander, John G. McNeil

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Longitudinal nonlinear mixed effects modeling of EGFR mutations in ctDNA as predictor of disease progression in treatment of EGFR‐mutant non‐small cell lung cancer by Julie M. Janssen, Remy B. Verheijen, Tirsa T. vanDuijl, Lishi Lin, Michel M. van denHeuvel, Jos H. Beijnen, Neeltje Steeghs, Daan van denBroek, Alwin D. R. Huitema, Thomas P. C. Dorlo

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GSTP1 and ABCB1 Polymorphisms Predicting Toxicities and Clinical Management on Carboplatin and Paclitaxel‐Based Chemotherapy in Ovarian Cancer by Amanda Canato Ferracini, Leisa Lopes-Aguiar, Gustavo Jacob Lourenço, Adriana Yoshida, Carmen Silva Passos Lima, Luis Otávio Sarian, Sophie Derchain, Deanna L. Kroetz, Priscila Gava Mazzola

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CYP2C19 loss‐of‐function alleles and use of omeprazole or esomeprazole increase the risk of cardiovascular outcomes in patients using clopidogrel by Markus Ramste, Markus Ritvos, Sergei Häyrynen, Johanna I. Kiiski, Mikko Niemi, Juha Sinisalo

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Randomized evaluation of the loss‐of‐function carboxylesterase 1 (CES1) G143E variant on clopidogrel and ticagrelor pharmacodynamics by Joshua P. Lewis, Kathleen A. Ryan, Elizabeth A. Streeten, Hilary B. Whitlatch, Melanie Daue, Keith Tanner, James A. Perry, Jeffrey R. O'Connell, Alan R. Shuldiner, Braxton D. Mitchell

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The relationship between high density lipoprotein cholesterol and sepsis: A clinical and genetic approach by Ge Liu, Lan Jiang, V. Eric Kerchberger, Annette Oeser, Andrea Ihegword, Alyson L. Dickson, Laura L. Daniel, Christian Shaffer, MacRae F. Linton, Nancy Cox, Cecilia P. Chung, Wei‐Qi Wei, C. Michael Stein, QiPing Feng

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Associations of CYP2C9 and CYP2C19 Pharmacogenetic Variation with Phenytoin‐Induced Cutaneous Adverse Drug Reactions by Alison E. Fohner, Allan E. Rettie, Khanh K. Thai, Dilrini K. Ranatunga, Brian L. Lawson, Vincent X. Liu, Catherine A. Schaefer

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Centering equity, diversity, and inclusion in youth digital mental health: findings from a research, policy, and practice knowledge exchange workshop by Medard Adu, Bilikis Banire, Bilikis Banire, Mya Dockrill, Alzena Ilie, Elizabeth Lappin, Patrick McGrath, Patrick McGrath, Samantha Munro, Kady Myers, Gloria Obuobi-Donkor, Rita Orji, Rebecca Pillai Riddell, Lori Wozney, Lori Wozney, Lori Wozney, Victor Yisa

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Predicting complex kidney drug handling using a physiologically‐based pharmacokinetic model informed by biomarker‐estimated secretory clearance and blood flow by Michael L. Granda, Weize Huang, Catherine K. Yeung, Nina Isoherranen, Bryan Kestenbaum

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Brain exposure of osimertinib in patients with epidermal growth factor receptor mutation non‐small cell lung cancer and brain metastases: A positron emission tomography and magneti... by Simon Ekman, Zsolt Cselényi, Andrea Varrone, Aurelija Jucaite, Heather Martin, Magnus Schou, Peter Johnström, Gianluca Laus, Rolf Lewensohn, Andrew P. Brown, Jasper van derAart, Karthick Vishwanathan, Lars Farde

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Follow-up analysis of federal process of care data reported from three acute care hospitals in rural Appalachia by Sills ES, Chiriac L, Vaughan D, Jones CA, Salem SA

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Serum cytokines to predict systemic lupus erythematosus clinical and serological activity by Victor Moreno‐Torres, Raquel Castejón, María Martínez‐Urbistondo, Ángela Gutiérrez‐Rojas, Jose Vázquez‐Comendador, Pablo Tutor, Pedro Durán‐del Campo, Susana Mellor‐Pita, Silvia Rosado, Juan‐Antonio Vargas‐Núñez

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Interrogation of CYP2D6 Structural Variant Alleles Improves the Correlation Between CYP2D6 Genotype and CYP2D6‐Mediated Metabolic Activity by Rachel Dalton, Seung‐been Lee, Katrina G. Claw, Bhagwat Prasad, Brian R. Phillips, Danny D. Shen, Lai Hong Wong, Mitch Fade, Matthew G. McDonald, Maitreya J. Dunham, Douglas M. Fowler, Allan E. Rettie, Erin Schuetz, Timothy A. Thornton, Deborah A. Nickerson, Andrea Gaedigk, Kenneth E. Thummel, Erica L. Woodahl

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Biomarker and pharmacodynamic activity of the transforming growth factor‐beta (TGFβ) inhibitor SAR439459 as monotherapy and in combination with cemiplimab in a phase I clinical stu... by Debbie Robbrecht, Jean‐Jacques Grob, Oliver Bechter, Matteo Simonelli, Bernard Doger, Ivan Borbath, Marcus O. Butler, Tina Cheng, Patricia Martin Romano, Elvire Pons‐Tostivint, Massimo Di Nicola, Giuseppe Curigliano, Min‐Hee Ryu, Alejo Rodriguez‐Vida, Dirk Schadendorf, Elena Garralda, Giovanni Abbadessa, Brigitte Demers, Amele Amrate, Hong Wang, Joon Sang Lee, Robert Pomponio, Rui Wang

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Model Informed Dosing Regimen and Phase I Results of the Anti‐PD‐1 Antibody Budigalimab (ABBV‐181) by John Powderly, Alexander Spira, Shunsuke Kondo, Toshihiko Doi, Jason J. Luke, Drew Rasco, Bo Gao, Minna Tanner, Philippe A. Cassier, Anas Gazzah, Antoine Italiano, Diego Tosi, Daniel E. Afar, Apurvasena Parikh, Benjamin Engelhardt, Stefan Englert, Stacie L. Lambert, Sreeneeranj Kasichayanula, Sven Mensing, Rajeev Menon, Gregory Vosganian, Anthony Tolcher

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