Search Results - Francis Poulenc~

Expanding the inhibitor space of the WWP1 and WWP2 HECT E3 ligases by Ashley P. Dudey, Jake M. Rigby, Gregory R. Hughes, G. Richard Stephenson, Thomas E. Storr, Andrew Chantry, Andrew M. Hemmings

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Synthesis, antiproliferative and antitrypanosomal activities, and DNA binding of novel 6-amidino-2-arylbenzothiazoles by Livio Racané, Valentina Rep, Sandra Kraljević Pavelić, Petra Grbčić, Iva Zonjić, Marijana Radić Stojković, Martin C. Taylor, John M. Kelly, Silvana Raić-Malić

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An affinity threshold for maximum efficacy in anti-PD-1 immunotherapy by Sarah C. Cowles, Allison Sheen, Luciano Santollani, Emi A. Lutz, Brianna M. Lax, Joseph R. Palmeri, Gordon J. Freeman, K. Dane Wittrup

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Highly potent inhibitors of cathepsin K with a differently positioned cyanohydrazide warhead: structural analysis of binding mode to mature and zymogen-like enzymes by Jakub Benýšek, Michal Buša, Petra Rubešová, Jindřich Fanfrlík, Martin Lepšík, Jiří Brynda, Zuzana Matoušková, Ulrike Bartz, Martin Horn, Michael Gütschow, Michael Mareš

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Mechanistic and biological characterisation of novel N5-substituted paullones targeting the biosynthesis of trypanothione in Leishmania by Andrea Medeiros, Diego Benítez, Ricarda S. Korn, Vinicius C. Ferreira, Exequiel Barrera, Federico Carrión, Otto Pritsch, Sergio Pantano, Conrad Kunick, Camila I. de Oliveira, Oliver C. F. Orban, Marcelo A. Comini

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Identification of novel pyrrolopyrimidine and pyrrolopyridine derivatives as potent ENPP1 inhibitors by Hee Jin Jeong, Hye Lim Lee, Sung Joon Kim, Jeong Hyun Jeong, Su Hyun Ji, Han Byeol Kim, Miso Kang, Hwan Won Chung, Chan Sun Park, Hyunah Choo, Hyo Jae Yoon, Nam-Jung Kim, Duck-Hyung Lee, Sanghee Lee, Seo-Jung Han

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Synthesis and characterisation of (Z)-styrylbenzene derivatives as potential selective anticancer agents by Ya-Bing Xin, Jia-Jun Li, Hong-Jian Zhang, Jun Ma, Xin Liu, Guo-Hua Gong, Yu-Shun Tian

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New classes of potent heparanase inhibitors from ligand-based virtual screening by Daniele Pala, Laura Scalvini, Gian Marco Elisi, Alessio Lodola, Marco Mor, Gilberto Spadoni, Fabiana F. Ferrara, Emiliano Pavoni, Giuseppe Roscilli, Ferdinando M. Milazzo, Gianfranco Battistuzzi, Silvia Rivara, Giuseppe Giannini

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Novel heterocyclic hybrids of pyrazole targeting dihydrofolate reductase: design, biological evaluation and in silico studies by Ismail M. M. Othman, Mohamed A. M. Gad-Elkareem, Abd El-Galil E. Amr, Mohamed A. Al-Omar, Eman S. Nossier, Elsayed A. Elsayed

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Design, synthesis, molecular modelling, and biological evaluation of novel substituted pyrimidine derivatives as potential anticancer agents for hepatocellular carcinoma by Naglaa Mohamed Ahmed, Mahmoud Youns, Moustafa Khames Soltan, Ahmed Mohammed Said

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Multivalent IgM scaffold enhances the therapeutic potential of variant-agnostic ACE2 decoys against SARS-CoV-2 by Meghan M. Verstraete, Florian Heinkel, Janessa Li, Siran Cao, Anh Tran, Elizabeth C. Halverson, Robert Gene, Elizabeth Stangle, Begonia Silva-Moreno, Sifa Arrafi, Jegarubee Bavananthasivam, Madeline Fung, Mariam Eji-Lasisi, Stephanie Masterman, Steve Xanthoudakis, Surjit Dixit, John Babcook, Brandon Clavette, Mark Fogg, Eric Escobar-Cabrera

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Development of a mechanism of action-reflective, dual target cell-based reporter bioassay for a bispecific monoclonal antibody targeting human CTLA-4 and PD-1 by Weimin Chen, Madhu Pandey, Hong Sun, Andrea Rolong, Mingyan Cao, Dengfeng Liu, Jihong Wang, Lingmin Zeng, Alan Hunter, Shihua Lin

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Development and characterization of standard reagents for cell-based prepandemic influenza vaccine products by Chia-Chun Lai, Tsai-Chuan Weng, Po-Ling Chen, Yu-Fen Tseng, Chun-Yang Lin, Min-Yuan Chia, Wang-Chou Sung, Min-Shi Lee, Alan Yung-Chih Hu

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Vaccine-induced CD8 T cells are redirected with peptide-MHC class I-IgG antibody fusion proteins to eliminate tumor cells in vivo by Cornelia Fischer, Michael W. Munks, Ann B. Hill, Richard A. Kroczek, Stefan Bissinger, Verena Brand, Martina Schmittnaegel, Sabine Imhof-Jung, Eike Hoffmann, Frank Herting, Christian Klein, Hendrik Knoetgen

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Contestations and complexities of nurses' participation in policy-making in South Africa by Prudence Ditlopo, Duane Blaauw, Loveday Penn-Kekana, Laetitia C. Rispel

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How is becoming pregnant whilst HIV-positive? Voices of women at a selected rural clinic in Mpumalanga Province of South Africa by Livhuwani Muthelo, Judith Prudence Mgwenya, Rambelani Nancy Malema, Tebogo Mothiba

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Design, synthesis, and evaluation of novel O-alkyl ferulamide derivatives as multifunctional ligands for treating Alzheimer's disease by Gaofeng Zhu, Ping Bai, Keren Wang, Jing Mi, Jing Yang, Jiaqi Hu, Yujuan Ban, Ran Xu, Rui Chen, Changning Wang, Lei Tang, Zhipei Sang

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Novel pyrazolo[3,4-d]pyrimidines: design, synthesis, anticancer activity, dual EGFR/ErbB2 receptor tyrosine kinases inhibitory activity, effects on cell cycle profile and caspase-3... by Mai Maher, Asmaa E. Kassab, Ashraf F. Zaher, Zeinab Mahmoud

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Leveraging on the genomics and immunopathology of SARS-CoV-2 for vaccines development: prospects and challenges by Idris Nasir Abdullahi, Anthony Uchenna Emeribe, Hafeez Aderinsayo Adekola, Sharafudeen Dahiru Abubakar, Amos Dangana, Halima Ali Shuwa, Sunday Theophilus Nwoba, Jelili Olaide Mustapha, Muyideen Titilope Haruna, Kafayat Adepeju Olowookere, Olawale Sunday Animasaun, Charles Egede Ugwu, Solomon Oloche Onoja, Abdullahi Sani Gadama, Musa Mohammed, Isa Muhammad Daneji, Dele Ohinoyi Amadu, Peter Elisha Ghamba, Nkechi Blessing Onukegbe, Muhammad Sagir Shehu, Chiladi Isomah, Adamu Babayo, Abdurrahman El-Fulaty Ahmad

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GLP1R boosts survival, migration and invasion of endometrial cancer cells and protects against ferroptotic cell death by Wu Li, Wen Lyu, Songjun Liu, Fan Ruan, Xinmei Zhang

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