Synthetic Biology Brings New Opportunity for Antibiotics Discovery

• Other Authors: Tong, Yaojun (Editor), Deng, Zixin (Editor), Bai, Linquan (Editor)
• Format: Electronic Book Chapter
• Language: English
• Published: Basel MDPI - Multidisciplinary Digital Publishing Institute 2023
• Subjects: Research & information: general; Biology, life sciences; global regulator; milbemycins; Streptomyces bingchenggensis; SspH; actinorhodin; avermectin; ceftriaxone; hepatotoxicity; metal complexes; oxidative stress; Streptomyces; comparative transcriptome; polyether antibiotics; salinomycin; exporter genes; spectroscopic studies; antioxidant capacities; hepatic functions; cancer cells; cefotaxime; Inonotus hispidus; natural product; biological activity; medicinal fungi; phytochemicals; antimicrobial agents; biosynthetic pathway; secondary metabolites; 1-benzazepine; l-kynurenine; genome mining; biosynthesis; iterative methyltransferase; genetic dereplication; cyclodipeptide; OSMAC; cytotoxicity; Zymomonas mobilis; antibiotic resistance; ampicillin; genome editing; CRISPR−Cas12a; resistance selection markers; traditional Chinese medicine; antifungal drug; immune regulation; combination of drugs; fungal infection; n/a
• Online Access: DOAB: download the publication; DOAB: description of the publication

We are facing a complicated public health issue in the form of global drug shortages, including antibiotics. Synthetic biology empowers the next generation of antibiotics development, bringing us into a new era.