Oncogenic Signaling of Growth Factor Receptors in Cancer: Mechanisms and Therapeutic Opportunities

• Other Authors: Dricu, Anica (Editor)
• Format: Electronic Book Chapter
• Language: English
• Published: Basel MDPI - Multidisciplinary Digital Publishing Institute 2023
• Subjects: Medicine; Oncology; oral cancer; autophagy; PI3K/AKT/mTOR signaling pathway; gastric cancer; HER3; heregulin; MET; SATB1; breast cancer; estrogen receptor-positive; HER2; PI3K/AKT/mTOR pathway; endocrine resistance; glioma; pathways; EGFR; clinical trials; gastric carcinoma; norepinephrine transporter; plasma free metanephrines and normetanephrines; coronavirus; pandemic; tyrosine kinase; receptor; signaling pathway; ELTD1; biomarker; angiogenesis; cancer; colorectal cancer; growth factors; PI3K/AKT/mTOR; MAPK; growth factor inhibitors; nivolumab; interleukin 10; T cells; cytokines; STAT3 pathway; AKT serine-threonine kinase pathway; MAP kinase pathway; single-cell RNA-seq; primary cerebral tumors; cancer stem-like cells; human neural stem cells; human neural progenitors; neurogenesis; gliogenesis; n/a
• Online Access: DOAB: download the publication; DOAB: description of the publication

At the molecular level, the activation of growth factor receptors (GFRs) induces a mitogenic response and maintains cancer cell growth. The majority of malignant diseases are related to aberrant intra- and intercellular communication, associated with the GFR-mediated pathways. Moreover, the evasion...