Optic Neuropathies Current and Future Strategies for Optic Nerve Protection and Repair

• Other Authors: Tsai, Rongkung (Editor), Miller, Neil R. (Editor)
• Format: Electronic Book Chapter
• Language: English
• Published: Basel MDPI - Multidisciplinary Digital Publishing Institute 2023
• Subjects: Medicine; neuroprotection; retinal ganglion cells; optic neuropathy; glaucoma; pattern electroretinogram; NMO; astrocytes; apoptosis; BID; inflammation; neuroimmunology; erythropoietin; retinal ganglion cell; optic nerve protection; neuromyelitis optica spectrum disease; aquaporin-4; myelin oligodendrocyte glycoprotein; ocular coherence tomography; complement; microcystic macular degeneration; Müller cell; astrocyte; oligodendrocyte; microglia; optic nerve head; lamina cribrosa; lamina cribrosa cells; scleral fibroblasts; glial cells; intraocular pressure; rat anterior ischemic optic neuropathy model; retinal ganglion cell death; TBP associated factor 9; TP53 regulated inhibitor of apoptosis 1; transcriptome; optic nerve; epigenetics; myelin; regeneration; oligodendrocytes; atypical optic neuritis treatment; typical optic neuritis; MOG; MS prevention; retina; transcription; CNS repair; oncomodulin; myeloid cells; glaucomatous optic neuropathy; fibrosis; miR-29; extracellular matrix; optic nerve crush; azithromycin; NAION; neural injury; neural ischemia; neural inflammation; Leber's hereditary optic neuropathy; LHON; whole exome sequencing; nuclear modifier genes; leber's hereditary optic neuropathy; mitochondrial disorder; mitochondrial optic neuropathy; hereditary optic neuropathy; neuro-ophthalmology; idebenone; nonarteritic anterior ischemic optic neuropathy; rodents; gene expression; models; diabetes; ischemic optic neuropathy; pioglitazone; HSF1; Klf4; Oct4; Sox2; Yamanaka factors; optic nerve regeneration; zebrafish; oligodendrocyte precursor cells; secondary degeneration; oxidative stress; DNA damage; proliferation; blood-brain barrier; CNS injury; optic nerve injury; synaptamide; A8; axonal degeneration; neuronal survival; visual evoked potential; n/a
• Online Access: DOAB: download the publication; DOAB: description of the publication

Optic neuropathies are conditions in which there is damage to the optic nerve (ON) caused by a variety of causes, including glaucoma, inflammation, gene abnormalities, ischemia, trauma, and toxicity. ON damage triggers a process of axon degeneration, inflammatory cytokine upregulation, breakdown of...