Stem Cells and Irradiation

• Other Authors: Chapel, Alain (Editor)
• Format: Electronic Book Chapter
• Language: English
• Published: Basel MDPI - Multidisciplinary Digital Publishing Institute 2023
• Subjects: Research & information: general; Biology, life sciences; human epidermis; keratinocytes; stem cells; precursor cells; low-dose γ irradiation; regeneration; dysplasia; epithelial-to-mesenchymal transition (EMT); ZEB1; experimental radiotherapy; radiobiology; mesenchymal stem cells; cell therapy; exosome; annexin A1; acute respiratory-distress syndrome; COVID-19; local radiation injuries; conditioned medium; cell technologies; X-ray radiation; skin; placenta; Radiation; stem/progenitor cells; organoids; radiation therapy; radiation cystitis; fibrosis; treatment; stem cells therapy; macrophages; mesenchymal stem cell; radiation damage; BCSC; ALDH activity; fractionated dose of γ radiation; radioresistance; ROS; Nrf2; Keap1; miR200a; epithelial-mesenchymal transition (EMT); colorectal cancer; cancer-stem like cells; SOX2; PI3K/AKT; radiation-induced injury; radiotherapy; radiation; mesenchymal; stem cell; extracellular vesicles; micro vesicles; paracrine effect; adipose tissue derived stem cells; n/a
• Online Access: DOAB: download the publication; DOAB: description of the publication

The main difficulty of radiotherapy is to destroy cancer cells without depletion of healthy tissue. Stem cells and cancers are tightly interrelated. On one hand, radiosensitivity/radioressistance of cancer stem cells affects the radiocurability of tumors. On the other hand, radiosensitivity is respo...