Stem Cells and Irradiation

The main difficulty of radiotherapy is to destroy cancer cells without depletion of healthy tissue. Stem cells and cancers are tightly interrelated. On one hand, radiosensitivity/radioressistance of cancer stem cells affects the radiocurability of tumors. On the other hand, radiosensitivity is respo...

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Bibliographic Details
Other Authors: Chapel, Alain (Editor)
Format: Electronic Book Chapter
Language:English
Published: Basel MDPI - Multidisciplinary Digital Publishing Institute 2023
Subjects:
Online Access:DOAB: download the publication
DOAB: description of the publication
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520 |a The main difficulty of radiotherapy is to destroy cancer cells without depletion of healthy tissue. Stem cells and cancers are tightly interrelated. On one hand, radiosensitivity/radioressistance of cancer stem cells affects the radiocurability of tumors. On the other hand, radiosensitivity is responsible for the stem cell depletion of organs at risk exposed to irradiation. Efficient solide cancer destruction is limited by the preservation of organ homeostasis. For this reason, targeted irradiation is an effective cancer therapy, but damage inflicted to normal tissues surrounding the tumor may cause severe complications. The consequences of stem cell depletion of healthy tissue irradiated are acute and chronic radiation diseases. Research on the radiosensitivity of cancer stem cells and adult stem cells associated with tissue regeneration medicine will bring forth the solution for optimal radiocurability associated with long-term patients' quality of life. 
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650 7 |a Biology, life sciences  |2 bicssc 
653 |a human epidermis 
653 |a keratinocytes 
653 |a stem cells 
653 |a precursor cells 
653 |a low-dose γ irradiation 
653 |a regeneration 
653 |a dysplasia 
653 |a epithelial-to-mesenchymal transition (EMT) 
653 |a ZEB1 
653 |a experimental radiotherapy 
653 |a radiobiology 
653 |a mesenchymal stem cells 
653 |a cell therapy 
653 |a exosome 
653 |a annexin A1 
653 |a acute respiratory-distress syndrome 
653 |a COVID-19 
653 |a local radiation injuries 
653 |a conditioned medium 
653 |a cell technologies 
653 |a X-ray radiation 
653 |a skin 
653 |a placenta 
653 |a Radiation 
653 |a stem/progenitor cells 
653 |a organoids 
653 |a radiation therapy 
653 |a radiation cystitis 
653 |a fibrosis 
653 |a treatment 
653 |a stem cells therapy 
653 |a macrophages 
653 |a mesenchymal stem cell 
653 |a radiation damage 
653 |a BCSC 
653 |a ALDH activity 
653 |a fractionated dose of γ radiation 
653 |a radioresistance 
653 |a ROS 
653 |a Nrf2 
653 |a Keap1 
653 |a miR200a 
653 |a epithelial-mesenchymal transition (EMT) 
653 |a colorectal cancer 
653 |a cancer-stem like cells 
653 |a SOX2 
653 |a PI3K/AKT 
653 |a radiation-induced injury 
653 |a radiotherapy 
653 |a radiation 
653 |a mesenchymal 
653 |a stem cell 
653 |a extracellular vesicles 
653 |a micro vesicles 
653 |a paracrine effect 
653 |a adipose tissue derived stem cells 
653 |a n/a 
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