Genetics and Epigenetics in Complex Diseases

Many of the most common diseases are influenced by a combination of multiple factors, which include environmental effectors as well as genetic and epigenetic variations. Therefore, these diseases are grouped under the term "complex" diseases because, from the point of view of genetics, the...

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Other Authors: Lopez-Lopez, Elixabet (Editor)
Format: Electronic Book Chapter
Language:English
Published: Basel MDPI - Multidisciplinary Digital Publishing Institute 2023
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DOAB: description of the publication
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520 |a Many of the most common diseases are influenced by a combination of multiple factors, which include environmental effectors as well as genetic and epigenetic variations. Therefore, these diseases are grouped under the term "complex" diseases because, from the point of view of genetics, they cannot be explained by simple Mendelian inheritance. The aim of this special issue was to identify genetic and epigenetic factors involved in such diseases in order to improve not only the knowledge of risk factors for those diseases, which could be of help for prevention, but also the understanding and characterization of each disease and to optimize and personalize the treatment. 
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653 |a chromatin remodeling 
653 |a circular RNA 
653 |a DNA methylation 
653 |a histone modification 
653 |a non-coding RNA 
653 |a oncogenes 
653 |a tumor suppressor genes 
653 |a tumor virus 
653 |a chronic lymphocytic leukemia 
653 |a CLL 
653 |a SF3B1 mutation 
653 |a NOTCH 
653 |a IKAROS 
653 |a syncope 
653 |a vasovagal syncope 
653 |a genetics 
653 |a complex disorders 
653 |a susceptibility 
653 |a twin studies 
653 |a family studies 
653 |a candidate gene association studies 
653 |a genome-wide studies 
653 |a acute myeloid leukemia 
653 |a pediatric 
653 |a trio sequencing 
653 |a germline cancer predisposition 
653 |a POT1 
653 |a shelterin complex 
653 |a psoriasis 
653 |a psoriatic arthritis 
653 |a NF-κB 
653 |a comorbidities 
653 |a genetic architecture 
653 |a SKP1 
653 |a CUL1 
653 |a RBX1 
653 |a SKP2 
653 |a FBXW7 
653 |a FBXO5 
653 |a SCF complex 
653 |a genome instability 
653 |a chromosome instability 
653 |a cancer 
653 |a VDBP 
653 |a vitamin D binding protein 
653 |a rs7041 
653 |a rs4588 
653 |a bone density 
653 |a diabetes 
653 |a obesity 
653 |a COPD 
653 |a pulmonary tuberculosis 
653 |a SNP 
653 |a MD 
653 |a PD 
653 |a CD33 
653 |a Alzheimer's disease 
653 |a sialic acid 
653 |a phagocytosis 
653 |a KLF14 
653 |a body shape indices 
653 |a metabolic traits 
653 |a differential effect 
653 |a genetic variants 
653 |a resistin 
653 |a soluble suppression of tumorigenicity 2 
653 |a weighted genetic risk score 
653 |a Taiwan Biobank 
653 |a coronary artery disease 
653 |a all-cause mortality 
653 |a major adverse cardiac events 
653 |a acute lymphoblastic leukemia 
653 |a RAD21 
653 |a cohesin complex 
653 |a n/a 
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