Pathogenesis and Novel Therapeutics in Asthma

• Other Authors: Bazan-Socha, Stanislawa (Editor)
• Format: Electronic Book Chapter
• Language: English
• Published: Basel MDPI - Multidisciplinary Digital Publishing Institute 2023
• Subjects: Medicine; bronchial epithelial cells; extracellular vesicles; miRNAs; airway epithelium; asthma; cellular compartmentalization; allergic rhinitis; allergen immunotherapy; bronchial asthma; component-resolved diagnosis; sublingual immunotherapy; fungal sensitization; IL-17A; Candida albicans; mediation effect; oxidative stress; CBA assay; airway remodeling; severe asthma; bronchial fibroblasts; fibrosis; Bcl10; NF-κB pathway; cytokines; efficacy; investigational; Phase I; Phase II; RCT; allergy; eosinophils; immune health; natural therapeutics; prostacyclin; allergic inflammation; proinflammatory; anti-inflammatory; BLT2; G-CSF; 12-LO; neutrophil; airway inflammation; n/a; miRNA; children; serum; exhaled breath condensate; diagnosis; exacerbation; biomarkers; factors
• Online Access: DOAB: download the publication; DOAB: description of the publication

Asthma is a prevalent chronic inflammatory disease of the airways with complex etiology and mechanistic pathways and variable clinical presentation. Such heterogeneity renders the search for targeted therapies difficult. Currently, the best-known disease phenotype with tailored biological treatment...