Inhibition of DNA Repair Enzymes as a Valuable Pharmaceutical Approach

• Other Authors: Volcho, Konstantin (Editor), Lavrik, Olga (Editor)
• Format: Electronic Book Chapter
• Language: English
• Published: Basel MDPI - Multidisciplinary Digital Publishing Institute 2023
• Subjects: Research & information: general; Biology, life sciences; poly (ADP-ribose) polymerase inhibitor; non-small cell lung cancer; DNA damage; radiotherapy; chemotherapy; combination therapy; coumarin; neoflavone; DNA repair enzymes; Tdp1 inhibitor; cancer; tumor; topotecan; topoisomerase 1 inhibitors; molecular modeling; chemical space; morpholino nucleosides; NAD+ analogs; DNA repair; PARP; 7-methylguanine; poly(ADP-ribose) polymerase 1; inhibitor; nucleosome; trapping; docking; molecular dynamics; fluorescence anisotropy; spFRET microscopy; DNA glycosylases; drug targets; APE1; protein-protein interactions; base excision repair; multifunctional disordered protein; fluorescence techniques; cell cycle checkpoint; cancer therapy; DNA repair inhibitors; synthetic lethality; fused in sarcoma; poly(ADP-ribose) polymerase; poly(ADP-ribose); protein phase separation; berberine; tetrahydroberberine; DNA repair enzyme; SAR; poly(ADP-ribosylation); PARP-1; Olaparib; KU55933; KU-0060648; SCR7 pyrazine; VERO cells; synergism; resistance; CDKN2A; soft tissue sarcomas (STS); gastrointestinal stromal tumors (GIST); AKT signaling; Rad51 recombinase; homology-mediated DNA repair; apoptosis; sensitization; XPA; ERCC1-XPF; CSB; UVB radiation; UVB mutagenesis; nucleotide excision repair (NER); cyclobutane-pyrimidine dimer (CPD) photolesion; veliparib; resveratrol; arsenic trioxide; spironolactone; usnic acid; thioether; tyrosyl-DNA phosphodiesterase 1; TDP1 inhibitor; inhibiting activity; TDP2; PARP1; synergy; HEK293 knockout cell line; polyphenols; PARP-1 inhibitors; n/a
• Online Access: DOAB: download the publication; DOAB: description of the publication

Although DNA repair enzymes play a crucial role in maintaining the integrity of the genome, the hyperactivity of certain enzymes of the DNA repair system can lead to the resistance of tumors to chemo- and radiotherapy, aimed at damaging the DNA of cancer cells. Therefore, the inhibition of DNA repai...