New Insights into Antithrombotic Therapy for Cardio- and Cerebrovascular Disease: From Molecular Mechanisms to Clinical Application

• Other Authors: Cimmino, Giovanni (Editor), Cirillo, Plinio (Editor)
• Format: Electronic Book Chapter
• Language: English
• Published: Basel MDPI - Multidisciplinary Digital Publishing Institute 2023
• Subjects: Medicine; Clinical & internal medicine; P2Y12 inhibitor; monotherapy; percutaneous coronary intervention; dual antiplatelet therapy; high bleeding risk; high on-treatment platelet reactivity; randomized controlled trial; left atrial appendage thrombus; atrial fibrillation; stroke; oral anticoagulant; cardiovascular diseases; novel antithrombotic agents; antiplatelet drugs; anticoagulants; hemostasis; factor XI; factor XI inhibitor; thrombosis; new drugs; left ventricular thrombus; anticoagulation; anterior wall myocardial infarction; dual therapy; direct oral anticoagulants; surface plasmon resonance; metformin; matrix metalloproteinase-9; plaque instability; atherosclerosis; cancer; acute coronary syndrome (ACS); percutaneous coronary intervention (PCI); dual antiplatelet therapy (DAPT); triple antithrombotic therapy (TAT); atrial fibrillation (AF); cardiotoxicity; aspirin; coronary artery disease; cerebrovascular disease; diabetes mellitus; essential thrombocythemia; platelet function; thromboxane; gastrointestinal bleeding; enteric-coated aspirin; cardiovascular prevention; P2Y12 inhibitors; acute coronary syndrome; clopidogrel; prasugrel; ticagrelor; cangrelor; selatogrel; zalunfiban; peripheral artery disease (PAD); antithrombotic therapy; dual pathway inhibition (DPI); major adverse cardiovascular events (MACE); major adverse limb events (MALE); n/a
• Online Access: DOAB: download the publication; DOAB: description of the publication

Thrombosis is a pathophysiological phenomenon observed in acute and chronic coronary syndrome, stroke, and peripheral artery disease. Exposure of the Tissue Factor (TF) to flowing blood is followed to its binding to other coagulation factors leading to thrombin formation. Together with platelet acti...