Biological Liquid-Liquid Phase Separation, Biomolecular Condensates, and Membraneless Organelles

• Other Authors: Uversky, Vladimir N. (Editor)
• Format: Electronic Book Chapter
• Language: English
• Published: Basel MDPI - Multidisciplinary Digital Publishing Institute 2023
• Subjects: Research & information: general; Biology, life sciences; Alzheimer's disease; amyloid aggregation; lipid bilayer; cholesterol; time-lapse AFM imaging; molecular dynamics; liquid-liquid phase separation (LLPS); membraneless organelles; phase-separated condensates; human diseases; liquid-liquid phase separation; intrinsically disordered proteins; proteins with low complexity; P-body; Nst1; polyampholyte domain; aggregation-prone domain; Saccharomyces cerevisiae; membrane-less organelle; nuclear speckle; nucleolus; phase separation; chromatin organization; nuclear condensate; intrinsically disordered region; transcription; DNA damage repair; super-enhancer; quantitative imaging; CTP synthase; cytoophidium; fluorescence recovery after photobleaching (FRAP); stimulated emission depletion (STED); Drosophila; epithelium; follicle cell; ingression; paramyxoviruses; Hendra virus; amyloid-like fibrils; Taylor Dispersion Analysis (TDA); negative staining Transmission Electron Microscopy (ns-TEM); Polyethylene glycol (PEG) precipitation assays; Congo Red; Small-Angle X-ray Scattering (SAXS); actin; actin polymerization; actin-binding proteins; coacervate; membrane; signaling proteins; n/a
• Online Access: DOAB: download the publication; DOAB: description of the publication

This reprint presents recent developments in the field of biological liquid-liquid phase separation (LLPS, also known as biomolecular condensation). LLPS and related biogenesis of various membraneless organelles (MLOs) and biomolecular condensates (BMCs) represent fundamental molecular mechanisms go...