Ubiquitination Governing DNA Repair Implications in Health and Disease

• Autres auteurs: Boutou, Effrossyni (Éditeur intellectuel), Stürzbecher, Horst-Werner (Éditeur intellectuel)
• Format: Électronique Chapitre de livre
• Langue: anglais
• Publié: IntechOpen 2018
• Sujets: Proteins; ubiquitylation, autophagy, dna damage, multiple myeloma, brca1, target therapy
• Accès en ligne: DOAB: download the publication; DOAB: description of the publication

DNA damage response (DDR) and lesion repair are vital processes ensuring genome integrity through various pathways depending mainly on the nature of DNA injury and cell cycle stage. DDR is finely regulated at many levels in co-ordination with other ongoing processes as is genome replication and cell...