Chapter 13 Targeting Tumor Perfusion and Oxygenation Modulates Hypoxia and Cancer Sensitivity to Radiotherapy and Systemic Therapies

Hypoxia, a partial pressure of oxygen (pO2) below physiological needs, is a limiting factor affecting the efficiency of radiotherapy. Indeed, the reaction of reactive oxygen species (ROS, produced by water radiolysis) with DNA is readily reversible unless oxygen stabilizes the DNA lesion. While no...

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Bibliographic Details
Main Author: Jordan, Bénédicte F. (auth)
Other Authors: Sonveaux, Pierre (auth)
Format: Electronic Book Chapter
Language:English
Published: InTechOpen 2011
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