Advances in Mechanisms of Renal Fibrosis
Scarring of the glomerular and tubulointerstitial compartments is a hallmark of progressive kidney disease. Renal fibrosis involves a complex interplay between kidney cells, leukocytes and fibroblasts in which transforming growth factor-β (TGF-β) plays a key role. This eBook provides a comprehensive...
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Other Authors: | |
Format: | Electronic Book Chapter |
Language: | English |
Published: |
Frontiers Media SA
2018
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Series: | Frontiers Research Topics
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Subjects: | |
Online Access: | DOAB: download the publication DOAB: description of the publication |
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Summary: | Scarring of the glomerular and tubulointerstitial compartments is a hallmark of progressive kidney disease. Renal fibrosis involves a complex interplay between kidney cells, leukocytes and fibroblasts in which transforming growth factor-β (TGF-β) plays a key role. This eBook provides a comprehensive update on TGF-β signalling pathways and introduces a range of cellular and molecular mechanisms involved in renal fibrosis both upstream and downstream of TGF-β. The wide variety of potential new targets described herein bodes well for the future development of effective therapies to tackle the major clinical problem of progressive renal fibrosis. |
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Physical Description: | 1 electronic resource (84 p.) |
ISBN: | 978-2-88945-499-0 9782889454990 |
Access: | Open Access |