Aging and Age-related Disorders: From Molecular Mechanisms to Therapies

• Main Author: Titorenko, Vladimir (auth)
• Format: Electronic Book Chapter
• Language: English
• Published: MDPI - Multidisciplinary Digital Publishing Institute 2019
• Subjects: Biology, life sciences; advanced glycated end products; microRNAs; n/a; differentiation; transcription; skin absorption; cellular quiescence; lifespan; longevity genes; protein kinases; self-renewal; circadian; blood-brain barrier; aging-related disorders; sirtuin-1; inflammation; arterial aging; reactive oxygen species; electron microscopy; reconstructed human skin; rejuvenation; low-dose fluvastatin and valsartan combination; inflammaging; hematopoietic stem cell aging; cell cycle; mitochondria; ribose; the nervous system; nanomedicine; proteostasis; adult stem cells; immunosenescence; cell signaling; mechanisms of quiescence maintenance; metabolism; aging; melatonin; diabetes; mechanisms of quiescence entry and exit; Drosophila melanogaster; GSK3 (glycogen synthase kinase 3)
• Online Access: DOAB: download the publication; DOAB: description of the publication

Aging of unicellular and multicellular eukaryotic organisms is a convoluted biological phenomenon, which is manifested as an age-related functional decline caused by progressive dysregulation of certain cellular and organismal processes. Many chronic diseases are associated with human aging. These a...