Amide Bond Activation

• 1. Verfasser: Szostak, Michal (auth)
• Format: Elektronisch Buchkapitel
• Sprache: Englisch
• Veröffentlicht: MDPI - Multidisciplinary Digital Publishing Institute 2019
• Schlagworte: Chemistry; N-heterocyclic carbene; non planar amide; ruthenium (Ru); physical organic chemistry; gemcitabine prodrug; pyramidal amides; bridged sultams; catalysis; dipeptides; N-(1-naphthyl)acetamide; C-N ? bond cleavage; steric effects; peptide bond cleavage; transition-metal-free; palladium; N-heterocyclic carbenes (NHCs); addition reaction; C-O activation; rhodium; metal complexes; carbanions; thioamidation; amide bond; intramolecular catalysis; antiviral activity; additivity principle; pre-catalysts; C-N bond cleavage; bridged lactams; C-H acidity; arynes; twisted amides; organic synthesis; amination; Suzuki-Miyaura; tert-butyl; cyclopentadienyl complexes; C-S formation; enzymes; DFT study; sulfonamide bond; N; HERON reaction; primaquine; entropy; amide activation; amidation; synthesis; amide hydrolysis; carbonylicity; amide bond activation; amide bond resonance; aminosulfonylation; molecular dynamics; model compound; in situ; amide; homogeneous catalysis; heterocycles; anomeric effect; multi-component coupling reaction; kinetic; excited state; C-H bond cleavage; palladium catalysis; amides; thiourea; formylation; alkynes; cis/trans isomerization; amide C-N bond activation; intein; C-H functionalization; succindiamide; amide bonds; crown ether; aminoacylation; directing groups; cytostatic activity; reaction thermodynamics; acyl transfer; transition metals; N-dimethylformamide; DMAc; acylative cross-coupling; C-H/C-N activation; nickel catalysis; antibacterial screening; sodium; aryl thioamides; Winkler-Dunitz parameters; catalyst; N-dimethylacetamide; base-catalyed hydrolysis; nitrogen heterocycles; cross-coupling; insertion; amidicity; nitro-aci tautomerism; activation; carbonylation; transamidation; amine; distortion; Pd-catalysis; rotational barrier energy; hypersensitivity; N-C activation; metabolic stability; [2+2+2] annulation; twisted amide; protease; cyanation; amide resonance; trialkylborane; catalysts; biofilm eradication; pharmacokinetics; pancreatic cancer cells; DMF; aryl esters; Michael acceptor; fumardiamide; water solvation; ester bond activation; cyclization; nuclear magnetic resonance; secondary amides; reaction mechanism; density functional theory; density-functional theory; amino acid transporters
• Online-Zugang: DOAB: download the publication; DOAB: description of the publication

The amide bond represents a privileged motif in chemistry. The recent years have witnessed an explosion of interest in the development of new chemical transformations of amides. These developments cover an impressive range of catalytic N-C bond activation in electrophilic, Lewis acid, radical, and n...