Bad Bugs in the XXIst Century: Resistance Mediated by Multi-Drug Efflux Pumps in Gram-Negative Bacteria

• Main Author: Hiroshi Nikaido (auth)
• Other Authors: Attilio Vittorio Vargiu (auth), Klaas Martinus Pos (auth), Keith Poole (auth)
• Format: Electronic Book Chapter
• Language: English
• Published: Frontiers Media SA 2016
• Series: Frontiers Research Topics
• Subjects: Microbiology (non-medical); Resistance-Nodulation Division transporters; multi-drug-resistant pathogens; antibiotic resistance; Gram-Negative Bacteria; bacterial resistance mechanisms; Superbugs; efflux pumps
• Online Access: DOAB: download the publication; DOAB: description of the publication

The discovery of antibiotics represented a key milestone in the history of medicine. However, with the rise of these life-saving drugs came the awareness that bacteria deploy defence mechanisms to resist these antibiotics, and they are good at it. Today, we appear at a crossroads between discovery o...