Biomimetic Radical Chemistry and Applications

• Main Author: Chatgilialoglu, Chryssostomos (auth)
• Format: Electronic Book Chapter
• Language: English
• Published: MDPI - Multidisciplinary Digital Publishing Institute 2020
• Subjects: Biology, life sciences; gold nanoparticles; inhomogeneous reactions; chemical nuclease; liposomal somatostatin; replication fork stalling; lipid bilayer membranes; 2c-3e S?S-bonded intermediates; cell micropolarity maps; protein labeling; time-resolved spectroscopy; 1; pulse radiolysis; nucleosides; 2-thiouracil; [1; lipidomics; radicals; reactive aldehydes; iron porphyrin; photolysis; oxidative damage; free fatty acids; charge transfer; fragmentation; biomimetic radical reaction; sulfones; bioinspired chemical catalysis; genomic and epigenomic instability; ATRPase; DNA methylation; oxononenal; trans lipid; copper; membrane fluidity maps; mitochondrial uncoupling protein; heme; thiyl radicals; oxidation; anomeric spironucleosides; protein stability; laser flash photolysis; type 2 diabetes; stationary radiolysis; confocal microscopy; iron(IV)-oxo; 5]-radical translocation; diabetes; DNA hole transfer; free radical oxidation; radical reaction; kinetic studies; circular dichroism; catalase activity; thiobases; intercalation; electron transfer; iron-mediated ATRP; Fenton reaction; EPR spectroscopy; glycogen phosphorylase; azidoalkylation; free radicals; gamma radiolysis; quantum dynamics; hydrogen peroxide; carboazidation; ?OH and ?N3 radicals; 5?; oligonucleotides; Raman spectroscopy; azides; peroxidation; photo-ionization; guanine quadruplexes; 8-cyclopurines; beta cells; cross-link; miRNAs; oxidative DNA damage; DNA damage; modified nucleosides; Julia-Kocienski olefination; DNA oxidation; therapeutic proteins; DNA replication stress; electron holes; singlet oxygen; radiosensitizers; cellular response; hydroxynonenal; isomerization; ?-radiolysis; histone modifications; 8-oxo-dG; 6-dioxa-4-azaspiro[4.5]decane; retarded delivery; reaction mechanism; DNA; albumin; TD-DFT methods; nucleobase derivatives; bio-mimicking catalyst
• Online Access: DOAB: download the publication; DOAB: description of the publication

The enormous importance of free radical chemistry for a variety of biological events, including ageing and inflammation, has attracted a strong interest in understanding the related mechanistic steps at the molecular level. Modelling the free radical chemical reactivity of biological systems is an i...