Carbonic Anhydrases and Metabolism

• Main Author: Supuran, Claudiu T. (auth)
• Format: Electronic Book Chapter
• Language: English
• Published: MDPI - Multidisciplinary Digital Publishing Institute 2019
• Subjects: Biology, life sciences; antibiotic; inhibitors; glaucoma; metabolic role; inhibitor; engineered bacteria; carbonic anhydrase inhibitors; drug discovery; enzyme inhibition; V-ATPases; photosynthesis; Chlamydomonas reinhardtii; metalloenzymes; CO2 capture; bicarbonate; benzamide; hypoxia; antibody; model alga; cancer therapeutics; CA gene family; resistance; isoforms IX and XII; cancer metabolism; MMP14; carbonic anhydrase IX; carboxylation; bacterial enzymes; antitumor agent; metabolism; activator; bacterial carbonic anhydrases; amine; amino acid; pH regulation; proton pump inhibitors; pathogens; sulfonamide; metastasis; hypoxic tumor; carbonic anhydrase; pH; carbonic anhydrases; protozoan; integrin; Entamoeba histolytica; tumors; human isoform; acidity; invasion; radiation; tumor; carbonic anhydrase XII; transporter; migration; cancer; tumor microenvironment
• Online Access: DOAB: download the publication; DOAB: description of the publication

Carbonic anhydrases (CAs; EC 4.2.1.1) are metalloenzymes present in all kingdoms of life, as they equilibrate the reaction between three simple but essential chemical species: CO2, bicarbonate, and protons. Discovered more than 80 years ago, in 1933, these enzymes have been extensively investigated...