CD4+ T cell differentiation in infection: amendments to the Th1/Th2 axiom

• Main Author: Carl G Feng (auth)
• Other Authors: Dragana Jankovic (auth)
• Format: Electronic Book Chapter
• Language: English
• Published: Frontiers Media SA 2015
• Series: Frontiers Research Topics
• Subjects: Medicine; Infection; Dendritic Cells; Cytokines; Immunoregulation; CD4 lymphocytes; Memory; long noncoding RNA; Macrophages; Metabolism; Th1 Th2
• Online Access: DOAB: download the publication; DOAB: description of the publication

CD4+ T lymphocytes play an essential role in host defense against bacterial, parasitic and viral infections. During infection, under the influence of intrinsic signals received through peptide-MHC/TCR interactions and extrinsic signals provided by pathogen-conditioned dendritic and other accessory c...