Cellular and molecular mechanisms of motor neuron death in amyotrophic lateral sclerosis

• Main Author: Ricardo Tapia (auth)
• Format: Electronic Book Chapter
• Language: English
• Published: Frontiers Media SA 2015
• Series: Frontiers Research Topics
• Subjects: Neurosciences; trophic factors; motor neuron degeneration; skeletal; neuroinflammation; muscle; genetic expression; spinal cord; amyotrophic lateral sclerosis (ALS)
• Online Access: DOAB: download the publication; DOAB: description of the publication

Amyotrophic lateral sclerosis (ALS), which was described since 1869 by Jean Martin Charcot, is a devastating neurodegenerative disease characterized by the selective and progressive loss of upper and lower motor neurons of the cerebral cortex, brainstem and the spinal cord. The cognitive process is...