Cellular Entry of Binary and Pore-Forming Bacterial Toxins

• Main Author: Alexey S. Ladokhin (Ed.) (auth)
• Format: Electronic Book Chapter
• Language: English
• Published: MDPI - Multidisciplinary Digital Publishing Institute 2018
• Subjects: Biology, life sciences; membrane permeabilization and translocation; toxin-membrane interactions; bacterial protein toxins; conformational switching; toxin-based targeted delivery of therapeutic agents; cellular uptake
• Online Access: DOAB: download the publication; DOAB: description of the publication

Bridging cellular membranes is a key step in the pathogenic action of both binary and pore-forming bacterial toxins. The former use their translocation domains, containing various structural motifs, to ensure efficient delivery of the toxic component into the host cell, while the latter act on the c...