Chemically-Induced DNA Damage, Mutagenesis, and Cancer

• Main Author: Takehiko Nohmi (Ed.) (auth)
• Other Authors: Ashis K. Basu (Ed.) (auth)
• Format: Electronic Book Chapter
• Language: English
• Published: MDPI - Multidisciplinary Digital Publishing Institute 2018
• Subjects: Biology, life sciences; genotoxicity; chemoprevention; DNA damage; metal toxicity; apoptosis; melanoma; tumor cells; DNA repair; chemotherapy; translesion synthesis
• Online Access: DOAB: download the publication; DOAB: description of the publication

Human cancers frequently arise from exposure to chemicals, although radiation, oxidation, and genetic factors play critical roles as well. DNA damage by these agents in a cell is an important first step in the process of carcinogenesis. DNA repair processes have evolved to repair these damages. Howe...