The Coevolution of IDO1 and AhR in the Emergence of Regulatory T Cells in Mammals

Indoleamine 2,3-dioxygenase (IDO1) is an ancestral enzyme that, initially confined to the regulation of tryptophan availability in local tissue microenvironments, is now considered to play a wider role that extends to homeostasis and plasticity of the immune system. Thus IDO biology has implications...

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Bibliographic Details
Main Author: Ursula Grohmann (auth)
Other Authors: Paolo Puccetti (auth)
Format: Electronic Book Chapter
Language:English
Published: Frontiers Media SA 2016
Series:Frontiers Research Topics
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