The Coevolution of IDO1 and AhR in the Emergence of Regulatory T Cells in Mammals

• Main Author: Ursula Grohmann (auth)
• Other Authors: Paolo Puccetti (auth)
• Format: Electronic Book Chapter
• Language: English
• Published: Frontiers Media SA 2016
• Series: Frontiers Research Topics
• Subjects: Medicine; Aryl hydrocarbon receptor (AhR); indoleamine dioxygenase 1 and 2 (IDO1 and IDO2); tryptophan dioxygenase (TDO2); tryptophan metabolism; Immune Regulation
• Online Access: DOAB: download the publication; DOAB: description of the publication

Indoleamine 2,3-dioxygenase (IDO1) is an ancestral enzyme that, initially confined to the regulation of tryptophan availability in local tissue microenvironments, is now considered to play a wider role that extends to homeostasis and plasticity of the immune system. Thus IDO biology has implications...