Computational and Experimental Approaches in Multi-Target Pharmacology

• Autor principal: Thomas J. Anastasio (auth)
• Formato: Recurso Eletrônico Capítulo de Livro
• Idioma: inglês
• Publicado em: Frontiers Media SA 2017
• coleção: Frontiers Research Topics
• Assuntos: Pharmacology; systems biology; computer modeling; drug repurposing; synergy; drug discovery; drug combination; high throughput screening; multidrug therapeutics; polypharmacy; multifactorial process
• Acesso em linha: DOAB: download the publication; DOAB: description of the publication

The next frontier in pharmacology is the development of multi-target strategies in which pathological processes are controlled by pharmacologically manipulating them at many different points at once. Designing multi-target strategies will require deep understanding of the complex physiology that und...