Diacylglycerol Kinase Signalling

• Main Author: Andrea Graziani (auth)
• Other Authors: Fumio Sakane (auth), Isabel Merida (auth)
• Format: Electronic Book Chapter
• Language: English
• Published: Frontiers Media SA 2017
• Series: Frontiers Research Topics
• Subjects: Biology, life sciences; T cell receptor; immunotherapy of cancer; immune system; synaptic transmission; synaptic plasticity (LTP/LTD); cytotoxic T cells; lipid signaling; tolerance
• Online Access: DOAB: download the publication; DOAB: description of the publication

Diacylglycerol kinases (DGKs) phosphorylate diacylglycerol (DG), catalyzing its conversion into phosphatidic acid (PA). This reaction attenuates membrane DG levels, limiting the localization/activation of signaling proteins that bind this lipid. Initially recognized as modulators of classical and no...