Disease and the Hippo Pathway: Cellular and Molecular Mechanisms

• Main Author: Hansen, Carsten Gram (auth)
• Format: Electronic Book Chapter
• Language: English
• Published: MDPI - Multidisciplinary Digital Publishing Institute 2019
• Subjects: Biology, life sciences; STRIPAK; skin cancer; n/a; Lats2; transcription; myofibroblast; epigenetic; Hippo; cancer immunity; TAZ; Taz; TAZ (transcriptional co-activator with PDZ-binding motif); adaptive immunity; fibroblasts; innate immunity; LATS; MST (mammalian STE20-like protein kinase); phosphorylation; stem cells; wound healing; signal transduction; angiogenesis; LATS1/2; EMT; protein-protein interactions; structure biology; Hippo pathway; hippo pathway; autoimmunity; Mps one binder; YAP/TAZ; GPCR; fibrosis; MST1/2; YAP (yes-associated protein); YAP; Yap; protein kinase; LATS (large tumor suppressor kinase); peripheral nerve sheath tumor; signal cross-talk; stem cell; skin development; STK38; tumorigenesis; NDR; schwannoma; G protein-coupled receptor; anti-cancer therapy; feedback loops; vascular mimicry; castration resistance; chromatin; Hippo signalling; ECM; MST; prostate cancer; TEAD; cancer; zebrafish
• Online Access: DOAB: download the publication; DOAB: description of the publication

The Hippo pathway is a highly dynamic cellular signaling nexus that plays central roles in multiple cell types and regulates regeneration, metabolism, and development. The Hippo pathway integrates mechanotransduction, cell polarity, inflammation, and numerous types of paracrine signaling. If not tig...