DNA Replication Stress

• Main Author: Brosh Jr, Robert M. (auth)
• Format: Electronic Book Chapter
• Language: English
• Published: MDPI - Multidisciplinary Digital Publishing Institute 2019
• Subjects: Biology, life sciences; Werner Syndrome; n/a; A549 cells; epigenetic; neurodegeneration; Genome integrity; adaptation; cellular senescence; genome instability; Werner Syndrome Protein; lipofuscin; cell cycle checkpoints; exonuclease 1; template-switching; energy metabolism; mutation frequency; DNA replication; fork regression; motor neuron disease; Microsatellites; Alzheimer's disease; chromatin remodeler; repair of DNA damage; AP site analogue; mutagens; replication timing; Thermococcus eurythermalis; nucleolar stress; gene expression; mutations spectra; origin firing; Fanconi Anemia; superfamily 2 ATPase; DNA translocation; DNA repair; SSB signaling; homologous recombination; common fragile sites; 8-chloro-adenosine; replication; genome stability; mutagenicity; fork reversal; multiple sclerosis; non-B DNA; protein stability; heterogeneity; ubiquitin; SenTraGorTM (GL13); replication restart; EdU; ?-arrestin; NER; aging; SSB end resection; oxidative stress; ATR; dormant origins; R loops; DNA damage response; Difficult-to-Replicate Sequences; DNA double-strand repair; endonuclease IV; ALS; double strand break repair; premature aging; replication stress; EXO1; POL?; translesion synthesis; strand displacements; G2-arrest; DNA replication pattern; SSB repair; genome integrity; G protein-coupled receptor kinase interacting protein 2 (GIT2); MMR; replicative stress; senolytics; spacer; interactome; ATR-Chk1 DDR pathway; C9orf72; replication fork restart; translesion DNA synthesis; DNA damage; mismatch repair; DNA replication stress; DNA helicase; Polymerase kappa; DNA fiber assay; H1299 cells; TLS; APE2; ageing; cell death; chromosome; TopBP1; barley; clock proteins; post-translational modification; 8-oxoG; S phase; ataxia telangiectasia mutated (ATM); G protein-coupled receptor (GPCR); Polymerase eta; cancer; G protein-coupled receptor kinase (GRK); helicase; genomic instability; Parkinson's disease; nucleotide excision repair; SupF
• Online Access: DOAB: download the publication; DOAB: description of the publication

This Special Issue of International Journal of Molecular Sciences (IJMS) is dedicated to the mechanisms mediated at the molecular and cellular levels in response to adverse genomic perturbations and DNA replication stress. The relevant proteins and processes play paramount roles in nucleic acid tran...