Drug Metabolism, Pharmacokinetics and Bioanalysis

• Hoofdauteur: Lee, Hye Suk (auth)
• Andere auteurs: Liu, Kwang-Hyeon (auth)
• Formaat: Elektronisch Hoofdstuk
• Taal: Engels
• Gepubliceerd in: MDPI - Multidisciplinary Digital Publishing Institute 2019
• Onderwerpen: Medicine; human liver microsomes; alcohol addiction; UGT; ultra-high-pressure liquid chromatography; adalimumab; procainamide; LC-MS/MS; DA-9805; paeonol; LC-QTOF-MS/MS; YRA-1909; chlorogenic acid; immunoprecipitation; Eurycoma longifolia; CYP; caffeic acid; rat; pharmaceutical excipient; Korean red ginseng extract; Stauntonia hexaphylla leaf extract; bioanalysis; HPLC-MS/MS; B6; eurycomanone; bioavailability; drying technology; GB3; diclofenac; 129-Glatm1Kul/J; aglycone; caffeic acid O-glucuronides; organic anion transporting polypeptide; protein precipitation; metabolic stability; Fabry disease; biopharmaceuticals; imperatorin; neochlorogenic acid; gastric ulcer; saikosaponin a; hair; anthraquinone; acetyl tributyl citrate; pharmacokinetics; brain distribution; mematine; ethyl glucuronide; pharmacokinetic; loxoprofen; liquid chromatography-quadrupole TOF MS; glucuronidation; esomeprazole; metformin; cytochrome P450; glycoside; AUDIT score; protein stability; efficacy; LC-HR/MS; cryptochlorogenic acid; aceclofenac; drug interaction; liquid chromatography-tandem mass spectrometry; Osthenol; plasma; N-acetylprocainamide; diabetes
• Online toegang: DOAB: download the publication; DOAB: description of the publication

Drug metabolism/pharmacokinetics and drug interaction studies have been extensively carried out in order to secure the druggability and safety of new chemical entities throughout the development of new drugs. Recently, drug metabolism and transport by phase II drug metabolizing enzymes and drug tran...