Dual Specificity Phosphatases: From Molecular Mechanisms to Biological Function

• Main Author: Pulido, Rafael (auth)
• Other Authors: Lang, Roland (auth)
• Format: Electronic Book Chapter
• Language: English
• Published: MDPI - Multidisciplinary Digital Publishing Institute 2019
• Subjects: Biology, life sciences; hematopoietic cells; DEPArray; n/a; neuroblastoma; liver steatosis; MAPK phosphatase; DUSP-4; granule neurons; neuronal differentiation; DUSP10; cytokines; MAPKs; single cell analysis; macrophage; asthma; E. coli infection; MAPK; Cpp1; nucleotide receptors; atypical DUSP; RSV; Pmp1; cannabinoids; astrocytes; sepsis; influenza; signaling; triple-negative breast cancer (TNBC); differentiation; HDAC6 (histone deacetylase isoform 6); atypical dual-specificity phosphatases; microtubules; respiratory viruses; MK-STYX (MAPK (mitogen-activated protein kinase) phosphoserine/threonine/tyrosine-binding protein); dual-specificity phosphatase; Msg5; TLR signaling; mitogen-activated protein kinase; fungal MKPs; macrophages; MAP Kinase Phosphatase-2; inflammation; Sdp1; circulating tumor cells (CTCs); MAP kinases; MAP kinase phosphatases; P2X7; proliferation; BDNF; P2Y13; T cell; hypertriglyceridemia; integrated omics analysis; post-translational modification; rhinovirus; protein stability; ubiquitination; dual-specificity phosphatases; Mkp-1; cancer; brain metastasis; HER2; COPD; pseudophosphatase
• Online Access: DOAB: download the publication; DOAB: description of the publication

Dual specificity phosphatases (DUSPs) constitute a heterogeneous group of protein tyrosine phosphatases with the ability to dephosphorylate Ser/Thr and Tyr residues from proteins, as well as from other non-proteinaceous substrates including signaling lipids. DUSPs include, among others, MAP kinase (...