Epitope Discovery and Synthetic Vaccine Design

• Main Author: Clarisa Beatriz Palatnik-de-Sousa (auth)
• Other Authors: Irene da Silva Soares (auth), Daniela Santoro Rosa (auth)
• Format: Electronic Book Chapter
• Language: English
• Published: Frontiers Media SA 2018
• Series: Frontiers Research Topics
• Subjects: Medicine; B-cell epitopes; in silico analysis; epitope prediction; multiepitope vaccines; carbohydrate vaccines; epitope vaccines; synthetic vaccines; immunoinformatics; T-cell epitopes
• Online Access: DOAB: download the publication; DOAB: description of the publication

Since variolation, conventional approaches to vaccine development are based on live-attenuated, inactivated or purified pathogen-derived components. However, effective vaccines against global health threats such as HIV, parasite infections and tumors are difficult to achieve. On the other hand, synt...