Evolution of NK-mediated target recognition under the pressure of physiologic or pathologic stimuli

• Main Author: Miguel Lopez-Botet (auth)
• Other Authors: Simona Sivori (auth), Daniel Olive (auth), Massimo Vitale (auth)
• Format: Electronic Book Chapter
• Language: English
• Published: Frontiers Media SA 2015
• Series: Frontiers Research Topics
• Subjects: Medicine; ILC; innate immunity; KIR; Autoimmune Diseases; decidual NK cell; NCR; anti-viral immune responses; anti-tumor immunity
• Online Access: DOAB: download the publication; DOAB: description of the publication

Since their discovery NK cells have come out as potential tools to fight cancer and viruses. This finding early urged different groups to study the mechanisms governing NK cell function. The identification of the MHC-I-specific inhibitory receptors (i.e. KIRs, NKG2A and certain Ly49 molecules) allow...