Evolution of NK-mediated target recognition under the pressure of physiologic or pathologic stimuli

• मुख्य लेखक: Miguel Lopez-Botet (auth)
• अन्य लेखक: Simona Sivori (auth), Daniel Olive (auth), Massimo Vitale (auth)
• स्वरूप: इलेक्ट्रोनिक पुस्तक अध्याय
• भाषा: अंग्रेज़ी
• प्रकाशित: Frontiers Media SA 2015
• श्रृंखला: Frontiers Research Topics
• विषय: Medicine; ILC; innate immunity; KIR; Autoimmune Diseases; decidual NK cell; NCR; anti-viral immune responses; anti-tumor immunity
• ऑनलाइन पहुंच: DOAB: download the publication; DOAB: description of the publication

Since their discovery NK cells have come out as potential tools to fight cancer and viruses. This finding early urged different groups to study the mechanisms governing NK cell function. The identification of the MHC-I-specific inhibitory receptors (i.e. KIRs, NKG2A and certain Ly49 molecules) allow...