Genetic Determinants of Human Longevity

• Main Author: Rose, Giuseppina (auth)
• Other Authors: Sørensen, Mette (auth), Dato, Serena (auth)
• Format: Electronic Book Chapter
• Language: English
• Published: MDPI - Multidisciplinary Digital Publishing Institute 2019
• Subjects: Genetics (non-medical); unknown zygosity; exceptional longevity; TERC; xenobiotic-metabolizing enzymes; lifespan; gender-specific association; long-livers; polymorphism; cumulative incidence curves; cardiovascular health; twins; genetic determinants of human longevity; TERT; SNP; moonlighting protein; longevity; genomics; APOE; polygenic risk score; signal transduction; xenobiotics; survival; IPMK; genetic variation; genetic association study; molecular senescence; zygosity; longevity-related genes; age-stratification; lipid profile; mortality; apolipoprotein E; aging; model systems; leukocyte telomere length; inositol phosphates; human lifespan; populations
• Online Access: DOAB: download the publication; DOAB: description of the publication

In the last two decades, due to the continuous increase of lifespans in Westernsocieties, and the consequent growing of the elderly population, have witnessedan increase in the number of studies on biological and molecular factors able topromote healthy aging and reach longevity. The study of the ge...