Glycolysis at 75: Is it time to tweak the first elucidated metabolic pathway in history?

• Main Author: Avital Schurr (auth)
• Other Authors: Evelyne Gozal (auth)
• Format: Electronic Book Chapter
• Language: English
• Published: Frontiers Media SA 2015
• Series: Frontiers Research Topics
• Subjects: Medicine; Traumatic Brain Injury; monocarboxylate tansporters; signaling; Energy Metabolism; Lactate; Glycolysis; lactate receptor; Lactate dehydrogenase; pyruvate; Cancer
• Online Access: DOAB: download the publication; DOAB: description of the publication

Glycolysis, the pathway of enzymatic reactions responsible for the breakdown of glucose into two trioses and further into pyruvate or lactate, was elucidated in 1940. For more than seven decades, it has been taught precisely the way its sequence was proposed by Embden, Meyerhof and Parnas. According...