Harnessing oncolytic virus-mediated immunity

• Main Author: Volker Schirrmacher (auth)
• Other Authors: Philippe Fournier (auth)
• Format: Electronic Book Chapter
• Language: English
• Published: Frontiers Media SA 2015
• Series: Frontiers Research Topics
• Subjects: Medicine; anti-tumor activity; immunovirotherapy; oncolytic virus; oncolytic virotherapy; tumor-associated antigen; immunotherapeutic approaches; anti-viral response
• Online Access: DOAB: download the publication; DOAB: description of the publication

Oncolytic viruses (OVs) have emerged as a promising anticancer treatment. OVs selectively infect, replicate in, and kill tumor cells. Oncolytic viral therapy occurs in two phases: an initial phase where the virus mediates direct oncolysis of tumor cells, and a second phase where an induced post-onco...