HIV-Induced Damage of B Cells and Production of HIV Neutralizing Antibodies

• Main Author: Francesca Chiodi (auth)
• Other Authors: Gabriella Scarlatti (auth)
• Format: Electronic Book Chapter
• Language: English
• Published: Frontiers Media SA 2018
• Series: Frontiers Research Topics
• Subjects: Medicine; auto-antibodies to CCR5; BAFF; Gene Expression; clinical potential of HIV-1 antibodies; mucosal IgA responses; FcRL4; neutralizing and non neutralizing HIV-1 antibodies; HIV-1 vaccine targets; B cells; CXCL13; maternal HIV antibodies
• Online Access: DOAB: download the publication; DOAB: description of the publication

Multiple dysfunctions take place in the B cell compartment during HIV-1 infection, comprising depletion of resting memory B cells carrying serological memory to vaccines and previously met pathogens. In addition, population of B cells characterized by the expression of exhaustion markers are enlarge...