HLA-G-mediated Immune Tolerance: Past and New Outlooks
The non-classical HLA class I molecule HLA-G is different from classical HLA class I molecules because of the low polymorphism in the coding region, the fact that HLA-G primary transcript is alternatively spliced in seven isoforms, and the inhibitory action on immune cells. Although HLA-G is low pol...
Saved in:
Main Author: | |
---|---|
Other Authors: | |
Format: | Electronic Book Chapter |
Language: | English |
Published: |
Frontiers Media SA
2017
|
Series: | Frontiers Research Topics
|
Subjects: | |
Online Access: | DOAB: download the publication DOAB: description of the publication |
Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
MARC
LEADER | 00000naaaa2200000uu 4500 | ||
---|---|---|---|
001 | doab_20_500_12854_49487 | ||
005 | 20210211 | ||
003 | oapen | ||
006 | m o d | ||
007 | cr|mn|---annan | ||
008 | 20210211s2017 xx |||||o ||| 0|eng d | ||
020 | |a 978-2-88945-119-7 | ||
020 | |a 9782889451197 | ||
040 | |a oapen |c oapen | ||
024 | 7 | |a 10.3389/978-2-88945-119-7 |c doi | |
041 | 0 | |a eng | |
042 | |a dc | ||
072 | 7 | |a M |2 bicssc | |
100 | 1 | |a Silvia Gregori |4 auth | |
700 | 1 | |a Joel LeMaoult |4 auth | |
245 | 1 | 0 | |a HLA-G-mediated Immune Tolerance: Past and New Outlooks |
260 | |b Frontiers Media SA |c 2017 | ||
300 | |a 1 electronic resource (92 p.) | ||
336 | |a text |b txt |2 rdacontent | ||
337 | |a computer |b c |2 rdamedia | ||
338 | |a online resource |b cr |2 rdacarrier | ||
490 | 1 | |a Frontiers Research Topics | |
506 | 0 | |a Open Access |2 star |f Unrestricted online access | |
520 | |a The non-classical HLA class I molecule HLA-G is different from classical HLA class I molecules because of the low polymorphism in the coding region, the fact that HLA-G primary transcript is alternatively spliced in seven isoforms, and the inhibitory action on immune cells. Although HLA-G is low polymorphic, variants in both promoter and 3' un-translated region (UTR) of HLA-G locus regulate its expression. In healthy conditions, a basal level of HLA-G gene transcription is observed in most cells and tissues; however, translation into HLA-G protein is restricted to trophoblasts in the placenta, where it participates in promoting tolerance at the fetal-maternal interface. HLA-G is also expressed by thymic epitelial, cornea, mesenchymal stem cells, nail matrix, pancreatic beta cells, erythroid, and endothelial precursors. HLA-G can be neo-expressed in adult tissues in pathological conditions, and its expression has been documented autoimmune disorders, viral infections, and cancer. In the latter setting de novo HLA-G expression is associated with the capability of tumor cells to evade the immune control. In the last decade it has become evident that HLA-G expression on T cells and antigenpresenting cells confers to these cells tolerogenic properties. This Research Topic focused on i) summarizing updated clinical and immunological evidences that HLA-G expression is associate with beneficial or detrimental tolerance, ii) gathering new insights into the mechanisms governing the expression of HLA-G in healthy and pathological conditions, such as pre-eclampsia, and iii) examining the mechanisms underlying HLA-G mediated tolerance. | ||
540 | |a Creative Commons |f https://creativecommons.org/licenses/by/4.0/ |2 cc |4 https://creativecommons.org/licenses/by/4.0/ | ||
546 | |a English | ||
650 | 7 | |a Medicine |2 bicssc | |
653 | |a Pregnancy | ||
653 | |a Autoimmunity | ||
653 | |a Immuno-modulation | ||
653 | |a Pre-Eclampsia | ||
653 | |a Infections | ||
653 | |a Exosomes | ||
653 | |a HLA-G | ||
653 | |a polymorphisms | ||
653 | |a tolerance | ||
653 | |a Cancer | ||
856 | 4 | 0 | |a www.oapen.org |u http://journal.frontiersin.org/researchtopic/2452/hla-g-mediated-immune-tolerance-past-and-new-outlooks |7 0 |z DOAB: download the publication |
856 | 4 | 0 | |a www.oapen.org |u https://directory.doabooks.org/handle/20.500.12854/49487 |7 0 |z DOAB: description of the publication |