HLA-G-mediated Immune Tolerance: Past and New Outlooks

• Main Author: Silvia Gregori (auth)
• Other Authors: Joel LeMaoult (auth)
• Format: Electronic Book Chapter
• Language: English
• Published: Frontiers Media SA 2017
• Series: Frontiers Research Topics
• Subjects: Medicine; Pregnancy; Autoimmunity; Immuno-modulation; Pre-Eclampsia; Infections; Exosomes; HLA-G; polymorphisms; tolerance; Cancer
• Online Access: DOAB: download the publication; DOAB: description of the publication

The non-classical HLA class I molecule HLA-G is different from classical HLA class I molecules because of the low polymorphism in the coding region, the fact that HLA-G primary transcript is alternatively spliced in seven isoforms, and the inhibitory action on immune cells. Although HLA-G is low pol...