HLA-G-mediated Immune Tolerance: Past and New Outlooks

• Autor principal: Silvia Gregori (auth)
• Outros Autores: Joel LeMaoult (auth)
• Formato: Recurso Electrónico Capítulo de Livro
• Idioma: inglês
• Publicado em: Frontiers Media SA 2017
• Colecção: Frontiers Research Topics
• Assuntos: Medicine; Pregnancy; Autoimmunity; Immuno-modulation; Pre-Eclampsia; Infections; Exosomes; HLA-G; polymorphisms; tolerance; Cancer
• Acesso em linha: DOAB: download the publication; DOAB: description of the publication

The non-classical HLA class I molecule HLA-G is different from classical HLA class I molecules because of the low polymorphism in the coding region, the fact that HLA-G primary transcript is alternatively spliced in seven isoforms, and the inhibitory action on immune cells. Although HLA-G is low pol...