HLA-G-mediated Immune Tolerance: Past and New Outlooks

• मुख्य लेखक: Silvia Gregori (auth)
• अन्य लेखक: Joel LeMaoult (auth)
• स्वरूप: इलेक्ट्रोनिक पुस्तक अध्याय
• भाषा: अंग्रेज़ी
• प्रकाशित: Frontiers Media SA 2017
• श्रृंखला: Frontiers Research Topics
• विषय: Medicine; Pregnancy; Autoimmunity; Immuno-modulation; Pre-Eclampsia; Infections; Exosomes; HLA-G; polymorphisms; tolerance; Cancer
• ऑनलाइन पहुंच: DOAB: download the publication; DOAB: description of the publication

The non-classical HLA class I molecule HLA-G is different from classical HLA class I molecules because of the low polymorphism in the coding region, the fact that HLA-G primary transcript is alternatively spliced in seven isoforms, and the inhibitory action on immune cells. Although HLA-G is low pol...